Predictors of clozapine response in schizophrenia

D. Pickar, R. R. Owen, R. E. Litman, J. K. Hsiao, T. P. Su

Research output: Contribution to journalArticle

Abstract

The introduction of the atypical neuroleptic, clozapine, has had widespread influence not only on the treatment of the seriously mentally ill patient, but also on new drug development and on hypotheses of the pathophysiology of schizophrenia. While clozapine differs from traditional neuroleptics in its lack of extrapyramidal side effects (EPS), it also is distinct in its profile of neurotransmitter receptor affinities. In our work examining the clinical and biological effects of clozapine in patients with schizophrenia, we have identified the presence of EPS during typical neuroleptic treatment as a consistent predictor of subsequent good response to clozapine. Further, our data suggest that clozapine should not be reserved for the most chronically ill patients, but rather be utilized in patients with less chronic courses of schizophrenia. Biological predictors of clozapine response are consistent with dopaminergic, serotonergic, and noradrenergic facets to its mechanism of action.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalJournal of Clinical Psychiatry
Volume55
Issue number9 SUPPL. B
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

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    Pickar, D., Owen, R. R., Litman, R. E., Hsiao, J. K., & Su, T. P. (1994). Predictors of clozapine response in schizophrenia. Journal of Clinical Psychiatry, 55(9 SUPPL. B), 129-132.