Predictive value of elevated LH/FSH ratio for ovulation induction in patients with polycystic ovary syndrome

Irene Woo, Kyle Tobler, Ayatallah Khafagy, Mindy Sue Christianson, Melissa Yates, Jairo Garcia

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess the value of an elevated luteinizing hormone (LH)–to–follicle-stimulating hormone (FSH) ratio in predicting development of a dominant follicle when ovulation induction is implemented with clomiphene citrate (CC) or letrozole in women with polycystic ovary syndrome (PCOS). STUDY DESIGN: Retrospective review of 312 monitored cycles between 2007 and 2012. All patients met the diagnostic criteria set by the 2006 Androgen Excess–PCOS Society and had baseline LH and FSH levels drawn. Only ovulation induction with CC or letrozole was included. Primary outcome was development of a dominant follicle of ≥18 mm. RESULTS: The development of a dominant follicle was significantly associated with clinical pregnancy. The development of a dominant follicle was also higher in the letrozole group as compared to the CC group (87.6% [155/177] vs. 62.2% [84/135], p

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume60
Issue number6
StatePublished - Dec 1 2015

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letrozole
Clomiphene
Ovulation Induction
Polycystic Ovary Syndrome
Luteinizing Hormone
Androgens
Hormones
Pregnancy

Keywords

  • Anovulation
  • Clomid
  • Clomiphene citrate
  • FSH (follicle-stimulating hormone)
  • Infertility
  • Letrozole
  • LH (luteinizing hormone)
  • LH/FSH ratio
  • Ovarian stimulation
  • Ovulation induction
  • Polycystic ovary syndrome
  • Reproductive technologies

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Predictive value of elevated LH/FSH ratio for ovulation induction in patients with polycystic ovary syndrome. / Woo, Irene; Tobler, Kyle; Khafagy, Ayatallah; Christianson, Mindy Sue; Yates, Melissa; Garcia, Jairo.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 60, No. 6, 01.12.2015, p. 495-500.

Research output: Contribution to journalArticle

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AU - Tobler, Kyle

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AU - Yates, Melissa

AU - Garcia, Jairo

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