Predictive sensitivity of human cancer cells in vivo using semipermeable polysulfone fibers

Ming Y.W. Chu, Milton H. Lipsky, Lorrin K. Yee, John Epstein, Katharine A. Whartenby, Scott Freeman, Tian M. Chen, Edward Chu, Edwin N. Forman, Paul Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

An in vivo experimental model was developed to predict efficiently and accurately chemosensitivity of human tumors. Human cancer cells either from cultured cell lines or from patients' tumors were injected directly into semipermeable polysulfone fibers subsequently implanted into immunocompetent rats. Results suggest utility of this novel model system for predicting tumor sensitivity to a wide range of anticancer agents and for potentially guiding the treatment of cancer patients in the clinical setting.

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalPharmacology
Volume56
Issue number6
DOIs
StatePublished - Jun 1 1998
Externally publishedYes

Keywords

  • Cancer
  • Drug testing
  • In vivo model

ASJC Scopus subject areas

  • Pharmacology

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