Abstract
An in vivo experimental model was developed to predict efficiently and accurately chemosensitivity of human tumors. Human cancer cells either from cultured cell lines or from patients' tumors were injected directly into semipermeable polysulfone fibers subsequently implanted into immunocompetent rats. Results suggest utility of this novel model system for predicting tumor sensitivity to a wide range of anticancer agents and for potentially guiding the treatment of cancer patients in the clinical setting.
Original language | English (US) |
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Pages (from-to) | 318-326 |
Number of pages | 9 |
Journal | Pharmacology |
Volume | 56 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1998 |
Externally published | Yes |
Keywords
- Cancer
- Drug testing
- In vivo model
ASJC Scopus subject areas
- Pharmacology