TY - JOUR
T1 - Predictive models for nanotoxicology
T2 - Current challenges and future opportunities
AU - Clark, Katherine A.
AU - White, Ronald H.
AU - Silbergeld, Ellen K.
PY - 2011/4
Y1 - 2011/4
N2 - Characterizing the risks posed by nanomaterials is extraordinarily complex because these materials can have a wide range of sizes, shapes, chemical compositions and surface modifications, all of which may affect toxicity. There is an urgent need for a testing strategy that can rapidly and efficiently provide a screening approach for evaluating the potential hazard of nanomaterials and inform the prioritization of additional toxicological testing where necessary. Predictive toxicity models could form an integral component of such an approach by predicting which nanomaterials, as a result of their physico-chemical characteristics, have potentially hazardous properties. Strategies for directing research towards predictive models and the ancillary benefits of such research are presented here.
AB - Characterizing the risks posed by nanomaterials is extraordinarily complex because these materials can have a wide range of sizes, shapes, chemical compositions and surface modifications, all of which may affect toxicity. There is an urgent need for a testing strategy that can rapidly and efficiently provide a screening approach for evaluating the potential hazard of nanomaterials and inform the prioritization of additional toxicological testing where necessary. Predictive toxicity models could form an integral component of such an approach by predicting which nanomaterials, as a result of their physico-chemical characteristics, have potentially hazardous properties. Strategies for directing research towards predictive models and the ancillary benefits of such research are presented here.
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U2 - 10.1016/j.yrtph.2011.02.002
DO - 10.1016/j.yrtph.2011.02.002
M3 - Comment/debate
C2 - 21310205
AN - SCOPUS:79952697349
SN - 0273-2300
VL - 59
SP - 361
EP - 363
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
IS - 3
ER -