Predictive factors of severe multilobar pneumonia and shock in patients with influenza

Susana Garcia Gutierrez; José Maria Quintana; Maretva Baricot; Amaia Bilbao; Alberto Capelastegui; Carlos Gustavo Cilla Eguiluz; Angela Domínguez; Jesús Castilla; Pere Godoy; Miguel Delgado-Rodríguez; Nuŕia Soldevila; Jenaro Astray; José María Mayoral; Vicente Martiń; Fernando Gonzaĺez-Candelas; Juan Carlos Galań; Sonia Tamames; Ady Angeĺica Castro-Acosta; Olatz Gariń; Tomaś Pumarola; M. A. Bueno; M. L. Gómez; M. Mariscal; B. Martínez; J. P. Quesada; M. Sillero; M. Carnero; J. Fernández-Crehuet; J. Del Diego Salas; V. Fuentes; V. Gallardo; E. Pérez; R. López; J. R. Maldonado; A. Morillo; I. Pedrosa Corral; M. F. Bautista; J. M. Navarro; M. Pérez; S. Oña; M. J. Pérez; M. C. Ubago; M. Zarzuela; P. Sanz; D. Carriedo; F. Díez; I. Fernández; S. Fernández; M. P. Sanz; J. J. Castrodeza; A. Pérez; R. De Ortiz Lejarazu; J. Ortiz; A. Pueyo; J. L. Viejo; A. Seco; P. Redondo; A. Molina; A. Agustí; A. Torres; A. Trilla; A. Vilella; F. Barbé; L. Blanch; G. Navarro; X. Bonfill; J. López-Contreras; V. Pomar; M. T. Puig; E. Borràs; A. Martínez; N. Torner; C. Bravo; F. Moraga; F. Calafell; J. Caylà; C. Tortajada; I. Garcia; J. Ruiz; J. J. García; J. Alonso; J. Gea; J. P. Horcajada; N. Hayes; A. Rosell; J. Dorca; Marc Saez; C. Álvarez; M. Enríquez; F. Pozo; F. Baquero; R. Cantón; A. Robustillo; M. Valdeón; E. Córdoba; F. Domínguez; J. García; R. Génova; E. Gil; S. Jiménez; M. A. Lopaz; J. López; F. Martín; M. L. Martínez; M. Ordobás; E. Rodriguez; S. Sánchez; C. Valdés; J. R. Paño; M. Romero; A. Martínez; L. Martínez; M. Ruiz; P. Fanlo; F. Gil; V. Martínez-Artola; J. M. Quintana; U. Aguirre; P. P. España; S. García; J. M. Antoñana; I. Astigarraga; J. I. Pijoan; I. Pocheville; M. Santiago; J. I. Villate; J. Arístegui; A. Escobar; M. I. Garrote; A. Bilbao; C. Garaizar; J. Korta; E. Pérez-Trallero; C. Sarasqueta; F. Aizpuru; J. L. Lobo; C. Salado; J. Alustiza; F. J. Troya; J. Blanquer; M. Morales

doi:10.1136/emermed-2012-202081

Predictive factors of severe multilobar pneumonia and shock in patients with influenza

Susana Garcia Gutierrez, José Maria Quintana, Maretva Baricot, Amaia Bilbao, Alberto Capelastegui, Carlos Gustavo Cilla Eguiluz, Angela Domínguez, Jesús Castilla, Pere Godoy, Miguel Delgado-Rodríguez, Nuŕia Soldevila, Jenaro Astray, José María Mayoral, Vicente Martiń, Fernando Gonzaĺez-Candelas, Juan Carlos Galań, Sonia Tamames, Ady Angeĺica Castro-Acosta, Olatz Gariń, Tomaś PumarolaM. A. Bueno, M. L. Gómez, M. Mariscal, B. Martínez, J. P. Quesada, M. Sillero, M. Carnero, J. Fernández-Crehuet, J. Del Diego Salas, V. Fuentes, V. Gallardo, E. Pérez, R. López, J. R. Maldonado, A. Morillo, I. Pedrosa Corral, M. F. Bautista, J. M. Navarro, M. Pérez, S. Oña, M. J. Pérez, M. C. Ubago, M. Zarzuela, P. Sanz, D. Carriedo, F. Díez, I. Fernández, S. Fernández, M. P. Sanz, J. J. Castrodeza, A. Pérez, R. De Ortiz Lejarazu, J. Ortiz, A. Pueyo, J. L. Viejo, A. Seco, P. Redondo, A. Molina, A. Agustí, A. Torres, A. Trilla, A. Vilella, F. Barbé, L. Blanch, G. Navarro, X. Bonfill, J. López-Contreras, V. Pomar, M. T. Puig, E. Borràs, A. Martínez, N. Torner, C. Bravo, F. Moraga, F. Calafell, J. Caylà, C. Tortajada, I. Garcia, J. Ruiz, J. J. García, J. Alonso, J. Gea, J. P. Horcajada, N. Hayes, A. Rosell, J. Dorca, Marc Saez, C. Álvarez, M. Enríquez, F. Pozo, F. Baquero, R. Cantón, A. Robustillo, M. Valdeón, E. Córdoba, F. Domínguez, J. García, R. Génova, E. Gil, S. Jiménez, M. A. Lopaz, J. López, F. Martín, M. L. Martínez, M. Ordobás, E. Rodriguez, S. Sánchez, C. Valdés, J. R. Paño, M. Romero, A. Martínez, L. Martínez, M. Ruiz, P. Fanlo, F. Gil, V. Martínez-Artola, J. M. Quintana, U. Aguirre, P. P. España, S. García, J. M. Antoñana, I. Astigarraga, J. I. Pijoan, I. Pocheville, M. Santiago, J. I. Villate, J. Arístegui, A. Escobar, M. I. Garrote, A. Bilbao, C. Garaizar, J. Korta, E. Pérez-Trallero, C. Sarasqueta, F. Aizpuru, J. L. Lobo, C. Salado, J. Alustiza, F. J. Troya, J. Blanquer, M. Morales

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose: To identify risk factors present at admission in adult patients hospitalised due to influenza virus infection during the 2009/10 and 2010/11 seasons - including whether infection was from pandemic or seasonal influenza A infections - that were associated with the likelihood of developing severe pneumonia with multilobar involvement and shock. Methods: Prospective cohort study. Patients hospitalised due to influenza virus infection were recruited. We collected information on sociodemographic characteristics, pre-existing medical conditions, vaccinations, toxic habits, previous medications, exposure to social environments, and EuroQoL-5D (EQ-5D). Severe pneumonia with multilobar involvement and/or shock (SPAS) was the primary outcome of interest. We constructed two multivariate logistic regression models to explain the likelihood of developing SPAS and to create a clinical prediction rule for developing SPAS that includes clinically relevant variables. Results: Laboratory-con firmed A(H1N1)pdm09, EQ-5D utility score 7 days before admission, more than one comorbidity, altered mental status, dyspnoea on arrival, days from onset of symptoms, and in fluenza season were associated with SPAS. In addition, not being vaccinated against seasonal influenza in the previous year, anaemia, altered mental status, fever and dyspnoea on arrival at hospital, difficulties in performing activities of daily living in the previous 7 days, and days from onset of symptoms to arrival at hospital were related to the likelihood of SPAS (area under the curve value of 0.75; Hosmer-Lemeshow p value of 0.84). Conclusions: These variables should be taken into account by physicians evaluating a patient affected by influenza as additional information to that provided by the usual risk scores.

Original language	English (US)
Pages (from-to)	301-307
Number of pages	7
Journal	Emergency Medicine Journal
Volume	31
Issue number	4
DOIs	https://doi.org/10.1136/emermed-2012-202081
State	Published - Apr 2014
Externally published	Yes

ASJC Scopus subject areas

Emergency Medicine
Critical Care and Intensive Care Medicine

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10.1136/emermed-2012-202081

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Gutierrez, S. G., Quintana, J. M., Baricot, M., Bilbao, A., Capelastegui, A., Eguiluz, C. G. C., Domínguez, A., Castilla, J., Godoy, P., Delgado-Rodríguez, M., Soldevila, N., Astray, J., Mayoral, J. M., Martiń, V., Gonzaĺez-Candelas, F., Galań, J. C., Tamames, S., Castro-Acosta, A. A., Gariń, O., ... Morales, M. (2014). Predictive factors of severe multilobar pneumonia and shock in patients with influenza. Emergency Medicine Journal, 31(4), 301-307. https://doi.org/10.1136/emermed-2012-202081

Gutierrez, SG, Quintana, JM, Baricot, M, Bilbao, A, Capelastegui, A, Eguiluz, CGC, Domínguez, A, Castilla, J, Godoy, P, Delgado-Rodríguez, M, Soldevila, N, Astray, J, Mayoral, JM, Martiń, V, Gonzaĺez-Candelas, F, Galań, JC, Tamames, S, Castro-Acosta, AA, Gariń, O, Pumarola, T, Bueno, MA, Gómez, ML, Mariscal, M, Martínez, B, Quesada, JP, Sillero, M, Carnero, M, Fernández-Crehuet, J, Del Diego Salas, J, Fuentes, V, Gallardo, V, Pérez, E, López, R, Maldonado, JR, Morillo, A, Pedrosa Corral, I, Bautista, MF, Navarro, JM, Pérez, M, Oña, S, Pérez, MJ, Ubago, MC, Zarzuela, M, Sanz, P, Carriedo, D, Díez, F, Fernández, I, Fernández, S, Sanz, MP, Castrodeza, JJ, Pérez, A, De Ortiz Lejarazu, R, Ortiz, J, Pueyo, A, Viejo, JL, Seco, A, Redondo, P, Molina, A, Agustí, A, Torres, A, Trilla, A, Vilella, A, Barbé, F, Blanch, L, Navarro, G, Bonfill, X, López-Contreras, J, Pomar, V, Puig, MT, Borràs, E, Martínez, A, Torner, N, Bravo, C, Moraga, F, Calafell, F, Caylà, J, Tortajada, C, Garcia, I, Ruiz, J, García, JJ, Alonso, J, Gea, J, Horcajada, JP, Hayes, N, Rosell, A, Dorca, J, Saez, M, Álvarez, C, Enríquez, M, Pozo, F, Baquero, F, Cantón, R, Robustillo, A, Valdeón, M, Córdoba, E, Domínguez, F, García, J, Génova, R, Gil, E, Jiménez, S, Lopaz, MA, López, J, Martín, F, Martínez, ML, Ordobás, M, Rodriguez, E, Sánchez, S, Valdés, C, Paño, JR, Romero, M, Martínez, A, Martínez, L, Ruiz, M, Fanlo, P, Gil, F, Martínez-Artola, V, Quintana, JM, Aguirre, U, España, PP, García, S, Antoñana, JM, Astigarraga, I, Pijoan, JI, Pocheville, I, Santiago, M, Villate, JI, Arístegui, J, Escobar, A, Garrote, MI, Bilbao, A, Garaizar, C, Korta, J, Pérez-Trallero, E, Sarasqueta, C, Aizpuru, F, Lobo, JL, Salado, C, Alustiza, J, Troya, FJ, Blanquer, J & Morales, M 2014, 'Predictive factors of severe multilobar pneumonia and shock in patients with influenza', Emergency Medicine Journal, vol. 31, no. 4, pp. 301-307. https://doi.org/10.1136/emermed-2012-202081

@article{727fad6a837648a1b273790fe5ccbcf7,

title = "Predictive factors of severe multilobar pneumonia and shock in patients with influenza",

abstract = "Purpose: To identify risk factors present at admission in adult patients hospitalised due to influenza virus infection during the 2009/10 and 2010/11 seasons - including whether infection was from pandemic or seasonal influenza A infections - that were associated with the likelihood of developing severe pneumonia with multilobar involvement and shock. Methods: Prospective cohort study. Patients hospitalised due to influenza virus infection were recruited. We collected information on sociodemographic characteristics, pre-existing medical conditions, vaccinations, toxic habits, previous medications, exposure to social environments, and EuroQoL-5D (EQ-5D). Severe pneumonia with multilobar involvement and/or shock (SPAS) was the primary outcome of interest. We constructed two multivariate logistic regression models to explain the likelihood of developing SPAS and to create a clinical prediction rule for developing SPAS that includes clinically relevant variables. Results: Laboratory-con firmed A(H1N1)pdm09, EQ-5D utility score 7 days before admission, more than one comorbidity, altered mental status, dyspnoea on arrival, days from onset of symptoms, and in fluenza season were associated with SPAS. In addition, not being vaccinated against seasonal influenza in the previous year, anaemia, altered mental status, fever and dyspnoea on arrival at hospital, difficulties in performing activities of daily living in the previous 7 days, and days from onset of symptoms to arrival at hospital were related to the likelihood of SPAS (area under the curve value of 0.75; Hosmer-Lemeshow p value of 0.84). Conclusions: These variables should be taken into account by physicians evaluating a patient affected by influenza as additional information to that provided by the usual risk scores.",

author = "Gutierrez, {Susana Garcia} and Quintana, {Jos{\'e} Maria} and Maretva Baricot and Amaia Bilbao and Alberto Capelastegui and Eguiluz, {Carlos Gustavo Cilla} and Angela Dom{\'i}nguez and Jes{\'u}s Castilla and Pere Godoy and Miguel Delgado-Rodr{\'i}guez and Nu{\'r}ia Soldevila and Jenaro Astray and Mayoral, {Jos{\'e} Mar{\'i}a} and Vicente Marti{\'n} and Fernando Gonza{\'l}ez-Candelas and Gala{\'n}, {Juan Carlos} and Sonia Tamames and Castro-Acosta, {Ady Ange{\'l}ica} and Olatz Gari{\'n} and Toma{\'s} Pumarola and Bueno, {M. A.} and G{\'o}mez, {M. L.} and M. Mariscal and B. Mart{\'i}nez and Quesada, {J. P.} and M. Sillero and M. Carnero and J. Fern{\'a}ndez-Crehuet and {Del Diego Salas}, J. and V. Fuentes and V. Gallardo and E. P{\'e}rez and R. L{\'o}pez and Maldonado, {J. R.} and A. Morillo and {Pedrosa Corral}, I. and Bautista, {M. F.} and Navarro, {J. M.} and M. P{\'e}rez and S. O{\~n}a and P{\'e}rez, {M. J.} and Ubago, {M. C.} and M. Zarzuela and P. Sanz and D. Carriedo and F. D{\'i}ez and I. Fern{\'a}ndez and S. Fern{\'a}ndez and Sanz, {M. P.} and Castrodeza, {J. J.} and A. P{\'e}rez and {De Ortiz Lejarazu}, R. and J. Ortiz and A. Pueyo and Viejo, {J. L.} and A. Seco and P. Redondo and A. Molina and A. Agust{\'i} and A. Torres and A. Trilla and A. Vilella and F. Barb{\'e} and L. Blanch and G. Navarro and X. Bonfill and J. L{\'o}pez-Contreras and V. Pomar and Puig, {M. T.} and E. Borr{\`a}s and A. Mart{\'i}nez and N. Torner and C. Bravo and F. Moraga and F. Calafell and J. Cayl{\`a} and C. Tortajada and I. Garcia and J. Ruiz and Garc{\'i}a, {J. J.} and J. Alonso and J. Gea and Horcajada, {J. P.} and N. Hayes and A. Rosell and J. Dorca and Marc Saez and C. {\'A}lvarez and M. Enr{\'i}quez and F. Pozo and F. Baquero and R. Cant{\'o}n and A. Robustillo and M. Valde{\'o}n and E. C{\'o}rdoba and F. Dom{\'i}nguez and J. Garc{\'i}a and R. G{\'e}nova and E. Gil and S. Jim{\'e}nez and Lopaz, {M. A.} and J. L{\'o}pez and F. Mart{\'i}n and Mart{\'i}nez, {M. L.} and M. Ordob{\'a}s and E. Rodriguez and S. S{\'a}nchez and C. Vald{\'e}s and Pa{\~n}o, {J. R.} and M. Romero and A. Mart{\'i}nez and L. Mart{\'i}nez and M. Ruiz and P. Fanlo and F. Gil and V. Mart{\'i}nez-Artola and Quintana, {J. M.} and U. Aguirre and Espa{\~n}a, {P. P.} and S. Garc{\'i}a and Anto{\~n}ana, {J. M.} and I. Astigarraga and Pijoan, {J. I.} and I. Pocheville and M. Santiago and Villate, {J. I.} and J. Ar{\'i}stegui and A. Escobar and Garrote, {M. I.} and A. Bilbao and C. Garaizar and J. Korta and E. P{\'e}rez-Trallero and C. Sarasqueta and F. Aizpuru and Lobo, {J. L.} and C. Salado and J. Alustiza and Troya, {F. J.} and J. Blanquer and M. Morales",

year = "2014",

month = apr,

doi = "10.1136/emermed-2012-202081",

language = "English (US)",

volume = "31",

pages = "301--307",

journal = "Emergency Medicine Journal",

issn = "1472-0205",

publisher = "BMJ Publishing Group",

number = "4",

}

TY - JOUR

T1 - Predictive factors of severe multilobar pneumonia and shock in patients with influenza

AU - Gutierrez, Susana Garcia

AU - Quintana, José Maria

AU - Baricot, Maretva

AU - Bilbao, Amaia

AU - Capelastegui, Alberto

AU - Eguiluz, Carlos Gustavo Cilla

AU - Domínguez, Angela

AU - Castilla, Jesús

AU - Godoy, Pere

AU - Delgado-Rodríguez, Miguel

AU - Soldevila, Nuŕia

AU - Astray, Jenaro

AU - Mayoral, José María

AU - Martiń, Vicente

AU - Gonzaĺez-Candelas, Fernando

AU - Galań, Juan Carlos

AU - Tamames, Sonia

AU - Castro-Acosta, Ady Angeĺica

AU - Gariń, Olatz

AU - Pumarola, Tomaś

AU - Bueno, M. A.

AU - Gómez, M. L.

AU - Mariscal, M.

AU - Martínez, B.

AU - Quesada, J. P.

AU - Sillero, M.

AU - Carnero, M.

AU - Fernández-Crehuet, J.

AU - Del Diego Salas, J.

AU - Fuentes, V.

AU - Gallardo, V.

AU - Pérez, E.

AU - López, R.

AU - Maldonado, J. R.

AU - Morillo, A.

AU - Pedrosa Corral, I.

AU - Bautista, M. F.

AU - Navarro, J. M.

AU - Pérez, M.

AU - Oña, S.

AU - Pérez, M. J.

AU - Ubago, M. C.

AU - Zarzuela, M.

AU - Sanz, P.

AU - Carriedo, D.

AU - Díez, F.

AU - Fernández, I.

AU - Fernández, S.

AU - Sanz, M. P.

AU - Castrodeza, J. J.

AU - Pérez, A.

AU - De Ortiz Lejarazu, R.

AU - Ortiz, J.

AU - Pueyo, A.

AU - Viejo, J. L.

AU - Seco, A.

AU - Redondo, P.

AU - Molina, A.

AU - Agustí, A.

AU - Torres, A.

AU - Trilla, A.

AU - Vilella, A.

AU - Barbé, F.

AU - Blanch, L.

AU - Navarro, G.

AU - Bonfill, X.

AU - López-Contreras, J.

AU - Pomar, V.

AU - Puig, M. T.

AU - Borràs, E.

AU - Martínez, A.

AU - Torner, N.

AU - Bravo, C.

AU - Moraga, F.

AU - Calafell, F.

AU - Caylà, J.

AU - Tortajada, C.

AU - Garcia, I.

AU - Ruiz, J.

AU - García, J. J.

AU - Alonso, J.

AU - Gea, J.

AU - Horcajada, J. P.

AU - Hayes, N.

AU - Rosell, A.

AU - Dorca, J.

AU - Saez, Marc

AU - Álvarez, C.

AU - Enríquez, M.

AU - Pozo, F.

AU - Baquero, F.

AU - Cantón, R.

AU - Robustillo, A.

AU - Valdeón, M.

AU - Córdoba, E.

AU - Domínguez, F.

AU - García, J.

AU - Génova, R.

AU - Gil, E.

AU - Jiménez, S.

AU - Lopaz, M. A.

AU - López, J.

AU - Martín, F.

AU - Martínez, M. L.

AU - Ordobás, M.

AU - Rodriguez, E.

AU - Sánchez, S.

AU - Valdés, C.

AU - Paño, J. R.

AU - Romero, M.

AU - Martínez, A.

AU - Martínez, L.

AU - Ruiz, M.

AU - Fanlo, P.

AU - Gil, F.

AU - Martínez-Artola, V.

AU - Quintana, J. M.

AU - Aguirre, U.

AU - España, P. P.

AU - García, S.

AU - Antoñana, J. M.

AU - Astigarraga, I.

AU - Pijoan, J. I.

AU - Pocheville, I.

AU - Santiago, M.

AU - Villate, J. I.

AU - Arístegui, J.

AU - Escobar, A.

AU - Garrote, M. I.

AU - Bilbao, A.

AU - Garaizar, C.

AU - Korta, J.

AU - Pérez-Trallero, E.

AU - Sarasqueta, C.

AU - Aizpuru, F.

AU - Lobo, J. L.

AU - Salado, C.

AU - Alustiza, J.

AU - Troya, F. J.

AU - Blanquer, J.

AU - Morales, M.

PY - 2014/4

Y1 - 2014/4

N2 - Purpose: To identify risk factors present at admission in adult patients hospitalised due to influenza virus infection during the 2009/10 and 2010/11 seasons - including whether infection was from pandemic or seasonal influenza A infections - that were associated with the likelihood of developing severe pneumonia with multilobar involvement and shock. Methods: Prospective cohort study. Patients hospitalised due to influenza virus infection were recruited. We collected information on sociodemographic characteristics, pre-existing medical conditions, vaccinations, toxic habits, previous medications, exposure to social environments, and EuroQoL-5D (EQ-5D). Severe pneumonia with multilobar involvement and/or shock (SPAS) was the primary outcome of interest. We constructed two multivariate logistic regression models to explain the likelihood of developing SPAS and to create a clinical prediction rule for developing SPAS that includes clinically relevant variables. Results: Laboratory-con firmed A(H1N1)pdm09, EQ-5D utility score 7 days before admission, more than one comorbidity, altered mental status, dyspnoea on arrival, days from onset of symptoms, and in fluenza season were associated with SPAS. In addition, not being vaccinated against seasonal influenza in the previous year, anaemia, altered mental status, fever and dyspnoea on arrival at hospital, difficulties in performing activities of daily living in the previous 7 days, and days from onset of symptoms to arrival at hospital were related to the likelihood of SPAS (area under the curve value of 0.75; Hosmer-Lemeshow p value of 0.84). Conclusions: These variables should be taken into account by physicians evaluating a patient affected by influenza as additional information to that provided by the usual risk scores.

AB - Purpose: To identify risk factors present at admission in adult patients hospitalised due to influenza virus infection during the 2009/10 and 2010/11 seasons - including whether infection was from pandemic or seasonal influenza A infections - that were associated with the likelihood of developing severe pneumonia with multilobar involvement and shock. Methods: Prospective cohort study. Patients hospitalised due to influenza virus infection were recruited. We collected information on sociodemographic characteristics, pre-existing medical conditions, vaccinations, toxic habits, previous medications, exposure to social environments, and EuroQoL-5D (EQ-5D). Severe pneumonia with multilobar involvement and/or shock (SPAS) was the primary outcome of interest. We constructed two multivariate logistic regression models to explain the likelihood of developing SPAS and to create a clinical prediction rule for developing SPAS that includes clinically relevant variables. Results: Laboratory-con firmed A(H1N1)pdm09, EQ-5D utility score 7 days before admission, more than one comorbidity, altered mental status, dyspnoea on arrival, days from onset of symptoms, and in fluenza season were associated with SPAS. In addition, not being vaccinated against seasonal influenza in the previous year, anaemia, altered mental status, fever and dyspnoea on arrival at hospital, difficulties in performing activities of daily living in the previous 7 days, and days from onset of symptoms to arrival at hospital were related to the likelihood of SPAS (area under the curve value of 0.75; Hosmer-Lemeshow p value of 0.84). Conclusions: These variables should be taken into account by physicians evaluating a patient affected by influenza as additional information to that provided by the usual risk scores.

UR - http://www.scopus.com/inward/record.url?scp=84896083900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896083900&partnerID=8YFLogxK

U2 - 10.1136/emermed-2012-202081

DO - 10.1136/emermed-2012-202081

M3 - Article

C2 - 23449891

AN - SCOPUS:84896083900

SN - 1472-0205

VL - 31

SP - 301

EP - 307

JO - Emergency Medicine Journal

JF - Emergency Medicine Journal

IS - 4

ER -

Predictive factors of severe multilobar pneumonia and shock in patients with influenza

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