Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer

Frans D. Rahusen, Hans Torrenga, Paul J. Van Diest, Rik Pijpers, Elsken Van Der Wall, Jappe Licht, Sybren Meijer

Research output: Contribution to journalArticle

Abstract

Background: The potential morbidity of an axillary lymph node dissection in patients with breast cancer can be avoided in patients with a negative sentinel node (SN). Hypothesis: It may be possible to identify a subset of patients with a positive SN and without metastases in the remaining axillary lymph nodes. Design: Case-control study. Setting: Both primary and referral hospital care. Patients: Data were studied for 255 consecutive patients with stage T1 or T2 breast cancer who had a successful identification of the SN. Interventions: In patients with a positive SN, histological examination of all non-SNs that were negative by routine examination was the same as that for SNs (multiple sectioning and immunohistochemical analysis). Main Outcome Measures: The incidence of non-SN metastases was correlated with the surface area and number of SN metastases and primary tumor characteristics. A micrometastasis was defined as less than 1 mm2. Results: Of 255 patients, the SN appeared to be positive in 93 (36%). Subsequent axillary lymph node dissection revealed positive non-SNs in 46 patients (49%). Patients with a single positive SN and patients with metastases less than 1 mm2 in the SN had significantly less non-SN involvement than patients with more than 1 positive SN (40% vs 78%) and patients with macrometastases (27% vs 49%). Conclusions: The incidence of non-SN metastases seemed to be related to the number of positive SNs and the size of SN metastases. However, in the group of patients with a positive SN, it was not possible to identify a subset of patients without non-SN metastases.

Original languageEnglish (US)
Pages (from-to)1059-1063
Number of pages5
JournalArchives of Surgery
Volume136
Issue number9
StatePublished - 2001
Externally publishedYes

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Breast Neoplasms
Neoplasm Metastasis
Lymph Node Excision
cyhalothrin
Neoplasm Micrometastasis
Incidence
Case-Control Studies
Referral and Consultation
Lymph Nodes
Outcome Assessment (Health Care)
Morbidity

ASJC Scopus subject areas

  • Surgery

Cite this

Rahusen, F. D., Torrenga, H., Van Diest, P. J., Pijpers, R., Van Der Wall, E., Licht, J., & Meijer, S. (2001). Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer. Archives of Surgery, 136(9), 1059-1063.

Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer. / Rahusen, Frans D.; Torrenga, Hans; Van Diest, Paul J.; Pijpers, Rik; Van Der Wall, Elsken; Licht, Jappe; Meijer, Sybren.

In: Archives of Surgery, Vol. 136, No. 9, 2001, p. 1059-1063.

Research output: Contribution to journalArticle

Rahusen, FD, Torrenga, H, Van Diest, PJ, Pijpers, R, Van Der Wall, E, Licht, J & Meijer, S 2001, 'Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer', Archives of Surgery, vol. 136, no. 9, pp. 1059-1063.
Rahusen FD, Torrenga H, Van Diest PJ, Pijpers R, Van Der Wall E, Licht J et al. Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer. Archives of Surgery. 2001;136(9):1059-1063.
Rahusen, Frans D. ; Torrenga, Hans ; Van Diest, Paul J. ; Pijpers, Rik ; Van Der Wall, Elsken ; Licht, Jappe ; Meijer, Sybren. / Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer. In: Archives of Surgery. 2001 ; Vol. 136, No. 9. pp. 1059-1063.
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