Predictive Factors Associated with Success and Failure for Calmare (Scrambler) Therapy: A Multicenter Analysis

Jee Youn Moon, Connie Kurihara, Judith P. Beckles, Karen E. Williams, David E. Jamison, Steven P. Cohen

Research output: Contribution to journalArticle

Abstract

Objective: Calmare (Scrambler) therapy is a novel therapeutic modality that purports to provide pain relief by "scrambling" afferent pain signals and replacing them with "non-pain" information through conventional lines of neural transmission. The goal of this study is to identify which factors are associated with treatment outcome for Calmare therapy. Methods: Data were garnered from 3 medical centers on 147 patients with various pain conditions who underwent a minimum of either 3 Calmare therapies on consecutive days or 5 therapies overall. A successful outcome was predefined as ≥50% pain relief on a 0 to 10 numerical rating scale that persisted for longer than 1 month after the last treatment. Variables evaluated for their association with outcome included age, sex, study site, baseline pain score, etiology, type of pain, diagnosis, treatment compliance, coexisting psychopathology, opioid use, antidepressant use, and membrane stabilizer use. Results: Overall, the success rate was 38.1%. Variables found to be associated with a positive outcome in multivariate logistic regression included the presence of neuropathic (OR=24.78; 95% CI, 2.47-248.97; P=0.006) or mixed (OR=10.52; 95% CI, 1.09-101.28; P=0.042) pain, and treatment at either Walter Reed (OR=6.87; 95% CI, 1.60-29.51; P=0.010) or Seoul National University (OR=12.29; 95% CI, 1.73-87.43; P=0.012). Factors that correlated with treatment failure were disease (OR=0.04; 95% CI, 0.002-0.59; P=0.020) or traumatic/surgical etiologies (OR=0.05; 95% CI, 0.005-0.56; P=0.015) and antidepressant use (OR=0.47; 95% CI, 0.18-1.02; P=0.056). Conclusions: A neuropathic or mixed neuropathic-nociceptive pain condition was associated with a positive treatment outcome. Investigators should consider these findings when developing selection criteria in clinical trials designed to determine the efficacy of Calmare therapy.

Original languageEnglish (US)
Pages (from-to)750-756
Number of pages7
JournalClinical Journal of Pain
Volume31
Issue number8
DOIs
StatePublished - Jul 23 2015

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Keywords

  • Calmare therapy
  • Scrambler therapy
  • chronic pain
  • outcome assessment
  • predictive value

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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