Predictions of capillary oxygen transport in the presence of fluorocarbon additives

Charles D. Eggleton, Tuhin K. Roy, Aleksander S Popel

Research output: Contribution to journalArticlepeer-review

Abstract

A mathematical model of capillary oxygen transport was formulated to determine the effect of increasing plasma solubility, e.g., by the addition of an intravascular fluorocarbon emulsion. The effect of increased plasma solubility is studied for two distributions of fluorocarbon, when the fluorocarbon droplets are uniformly distributed throughout the plasma and when the fluorocarbon droplets are concentrated in a layer adjacent to the endothelium. The model was applied to working hamster retractor muscle at normal and lowered hematocrit. The intracapillary mass transfer coefficient was found to increase by 18% as the solubility was increased by a factor of 1.7 at a hematocrit of 43%. An additional increase of 6% was predicted when the solubility increase was concentrated in the layer adjacent to the endothelium. At a hematocrit of 25%, the intracapillary mass transfer coefficient increased 14% when the solubility was increased by a factor of 1.7.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume44
Issue number6
StatePublished - Dec 1998

Keywords

  • Blood substitute
  • Hamster retractor muscle
  • Mass transfer coefficient
  • Mathematical model
  • Microcirculation

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Predictions of capillary oxygen transport in the presence of fluorocarbon additives'. Together they form a unique fingerprint.

Cite this