Prediction of treatment outcomes in psychiatry-where do we stand?

Francis J. McMahon

Research output: Contribution to journalArticlepeer-review


Psychiatric treatment relies on a solid armamentarium of pharmacologic and nonpharmacologic treatment modalities that perform reasonably well for many patients but leave others in a state of chronic disability or troubled by problematic side effects. Treatment planning in psychiatry remains an art that depends on considerable trial and error. Thus, there is an urgent need for better tools that will provide a means for matching individual patients with the most effective treatments while minimizing the risk of adverse events. This review will consider the current state of the science in predicting treatment outcomes in psychiatry. Genetic and other biomarkers will be considered alongside clinical, diagnostic, and family history data. Problems inherent in prediction medicine will also be discussed, along with recent developments that support the hope that psychiatry can do a better job in quickly identifying the best treatments for each patient.

Original languageEnglish (US)
Pages (from-to)455-464
Number of pages10
JournalDialogues in Clinical Neuroscience
Issue number4
StatePublished - 2014


  • Adverse event
  • Biomarker
  • Personalized medicine
  • Pharmacogenetics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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