Prediction of tissue survival after stroke based on changes in the apparent diffusion of water (cytotoxic edema)

M. Sakoh, T. Olmishi, L. Ostergaard, A. Gjedde

Research output: Contribution to journalArticle

Abstract

This study tested the hypothesis that the estimate of the apparent diffusion coefficient (ADC; an index of Cytotoxic edema) of water is a rehable pathophysiological index of the viability of ischemic brain tissue. CBF, the partition volume of water (PVW; an index of vasogenic edema), cerebral metabolic rate of oxygen (CMRO2), and of glucose (CMRcic) were measured before and after permanent middle cerebral artery occlusion (MCAO) or reperfusion with positron emission tomography (PET) in pigs. Then, the ADC was measured by difiusion-weighted magnetic resonance imaging (DW-MRI) and was compared with physiological variables obtained by PET and with histological findings. Both after permanent MCAO and reperfusion, the ADC was significantly correlated to the CMRO2 and CMRcic. The sequential decrease of ADC was also correlated to the sequential reduction of CMRO 2 in relation to the residual CBF after permanent MCAO. The infarction coincided with a threshold CMRO2 of 50% of the contralateral value and a threshold ADC of 75% of the contralateral value, respectively. The PVW was decreased in relation to the magnitude of residual CBF after MCAO, whereas it was transiently increased in the severely ischemic lesions below 75% of the contralateral ADC value after reperfusion. Thus, the ADC is a reliable pathophysiological index which allows therapy to be tailored to the condition of individual patients in clinical practice.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalActa Neurochirurgica, Supplement
Issue number86
StatePublished - 2003
Externally publishedYes

Fingerprint

Tissue Survival
Middle Cerebral Artery Infarction
Edema
Stroke
Reperfusion
Water
Positron-Emission Tomography
Brain Edema
Infarction
Swine
Magnetic Resonance Imaging
Oxygen
Glucose
Brain
Therapeutics

Keywords

  • Apparent diffusion coefficient
  • Cerebral metabolic rate of oxygen
  • Diffusion weighted imaging
  • Ischemia
  • Positron emission tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

Prediction of tissue survival after stroke based on changes in the apparent diffusion of water (cytotoxic edema). / Sakoh, M.; Olmishi, T.; Ostergaard, L.; Gjedde, A.

In: Acta Neurochirurgica, Supplement, No. 86, 2003, p. 137-140.

Research output: Contribution to journalArticle

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