Prediction of severe disseminated adenovirus infection by serum PCR

Marcela Echavarria, Michael Forman, Maarten J.D. Van Tol, Jaak M. Vossen, Patricia Charache, Aloys C.M. Kroes

Research output: Contribution to journalArticlepeer-review

Abstract

Adenoviruses are increasingly recognised as viral pathogens that can cause fatal infections in immunocompromised patients, particularly recipients of haematopoietic stem-cell grafts. Adenovirus infections are not easily diagnosed and the development of a severe infection cannot be predicted by standard culture techniques. In a pilot study, we investigated the value of adenovirus DNA detection in serum as a marker of disseminated disease in 14 patients with defined patterns of adenovirus infections. The results show that the appearance of adenoviral DNA in serum preceded the development of a severe or fatal adenovirus infection. Because proper management is dependent on early diagnosis and differentiation from other conditions, this test may be a valuable tool in the management of adenovirus infection.

Original languageEnglish (US)
Pages (from-to)384-385
Number of pages2
JournalLancet
Volume358
Issue number9279
DOIs
StatePublished - Aug 4 2001

ASJC Scopus subject areas

  • Medicine(all)

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