Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy

Gabriella Captur, Luis R. Lopes, Timothy J. Mohun, Vimal Patel, Chunming Li, Paul Bassett, Gherardo Finocchiaro, Vanessa M. Ferreira, Maite Tome Esteban, Vivek Muthurangu, Mark V. Sherrid, Sharlene M. Day, Charles E. Canter, William J. McKenna, Christine E. Seidman, David A. Bluemke, Perry M. Elliott, Carolyn Y. Ho, James C. Moon

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH). We have proposed that myocardial crypts are part of this phenotype and independently associated with the presence of sarcomere gene mutations. We tested this hypothesis in genetic hypertrophic cardiomyopathy pre-LVH (genotype positive, LVH negative [G+LVH-]). Methods and Results: A multicenter case-control study investigated crypts and 22 other cardiovascular magnetic resonance parameters in subclinical hypertrophic cardiomyopathy to determine their strength of association with sarcomere gene mutation carriage. The G+LVH- sample (n=73) was 29±13 years old and 51% were men. Crypts were related to the presence of sarcomere mutations (for ≥1 crypt, β=2.5; 95% confidence interval [CI], 0.5-4.4; P=0.014 and for ≥2 crypts, β=3.0; 95% CI, 0.8-7.9; P=0.004). In combination with 3 other parameters: anterior mitral valve leaflet elongation (β=2.1; 95% CI, 1.7-3.1; P<0.001), abnormal LV apical trabeculae (β=1.6; 95% CI, 0.8-2.5; P<0.001), and smaller LV end-systolic volumes (β=1.4; 95% CI, 0.5-2.3; P=0.001), multiple crypts indicated the presence of sarcomere gene mutations with 80% accuracy and an area under the curve of 0.85 (95% CI, 0.8-0.9). In this G+LVH- population, cardiac myosin-binding protein C mutation carriers had twice the prevalence of crypts when compared with the other combined mutations (47 versus 23%; odds ratio, 2.9; 95% CI, 1.1-7.9; P=0.045). Conclusions: The subclinical hypertrophic cardiomyopathy phenotype measured by cardiovascular magnetic resonance in a multicenter environment and consisting of crypts (particularly multiple), anterior mitral valve leaflet elongation, abnormal trabeculae, and smaller LV systolic cavity is indicative of the presence of sarcomere gene mutations and highlights the need for further study.

Original languageEnglish (US)
Pages (from-to)863-871
Number of pages9
JournalCirculation: Cardiovascular Imaging
Volume7
Issue number6
DOIs
StatePublished - Nov 1 2014

Keywords

  • Cardiomyopathy hypertrophic
  • Genetics
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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