Abstract
Protein-protein interactions play important roles in many biological progresses. Previous studies about proteinprotein interactions were mainly based on sequence analysis. As more 3D structural information can be obtained from protein-protein complexes, structural analysis becomes feasible and useful. In this study, we used structural alignment to predict protein-binding sites and analyzed interface properties using 3D alpha shape. We have developed a method for protein-protein interaction prediction. The result indicates good performance of our method in discriminating proteinbinding structures from non-protein-binding structures. In the experiment, our method shows best Matthews correlation coefficient of 0.204.
Original language | English (US) |
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Pages (from-to) | 3-8 |
Number of pages | 6 |
Journal | Current Bioinformatics |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 2013 |
Externally published | Yes |
Keywords
- Alpha shape
- Protein-protein interaction
- Structural alignment
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics
- Computational Mathematics