Predicting the outcome of endometrial hyperplasia by quantitative analysis of nuclear features using a linear discriminant function

Terry J. Colgan, Henry J. Norris, Walter Foster, Robert J. Kurman, Cecil H. Fox

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear parameters from 24 cases of atypical endometrial hyperplasia were determined by means of graphic tablet and microcomputer. Eight of the 24 hyperplasias progressed to carcinoma, but the remaining 16 did not progress during a mean follow-up period of 11.8 years. A linear discriminant function selected the mean and standard deviation of maximal nuclear diameter as useful predictors of clinical outcome. The linear discriminant function predicted the correct outcome in 83% of the cases. This study suggests that measurement of nuclear parameters in atypical endometrial hyperplasia may provide a more objective means of predicting the behavior of the various forms of hyperplasia.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalInternational Journal of Gynecological Pathology
Volume1
Issue number4
DOIs
StatePublished - Jan 1983
Externally publishedYes

Keywords

  • Atypical endometrial hyperplasia
  • Carcinoma
  • Linear discriminant function
  • Stepwise analysis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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