Predicting postoperative quality-of-life outcomes in patients with metastatic spine disease: Who benefits?

James Feghali, Zach Pennington, Jeff Ehresman, Daniel Lubelski, Ethan Cottrill, A. Karim Ahmed, Andrew Schilling, Daniel M. Sciubba

Research output: Contribution to journalArticlepeer-review


Symptomatic spinal metastasis occurs in around 10% of all cancer patients, 5%-10% of whom will require operative management. While postoperative survival has been extensively evaluated, postoperative health-related quality-of-life (HRQOL) outcomes have remained relatively understudied. Available tools that measure HRQOL are heterogeneous and may emphasize different aspects of HRQOL. The authors of this paper recommend the use of the EQ-5D and Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ), given their extensive validation, to capture the QOL effects of systemic disease and spine metastases. Recent studies have identified preoperative QOL, baseline functional status, and neurological function as potential predictors of postoperative QOL outcomes, but heterogeneity across studies limits the ability to derive meaningful conclusions from the data. Future development of a valid and reliable prognostic model will likely require the application of a standardized protocol in the context of a multicenter study design.

Original languageEnglish (US)
Pages (from-to)383-389
Number of pages7
JournalJournal of Neurosurgery: Spine
Issue number3
StatePublished - Mar 2021


  • Oncology
  • Patient selection
  • Predictive analytics
  • Quality of life
  • Spinal metastases

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology


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