TY - JOUR
T1 - Predicting malaria transmission dynamics in dangassa, mali
T2 - A novel approach using functional generalized additive models
AU - Ateba, François Freddy
AU - Febrero-Bande, Manuel
AU - Sagara, Issaka
AU - Sogoba, Nafomon
AU - Touré, Mahamoudou
AU - Sanogo, Daouda
AU - Diarra, Ayouba
AU - Ngitah, Andoh Magdalene
AU - Winch, Peter J.
AU - Shaffer, Jeffrey G.
AU - Krogstad, Donald J.
AU - Marker, Hannah C.
AU - Gaudart, Jean
AU - Doumbia, Seydou
N1 - Funding Information:
Funding: The project at the base of the study used in this work was supported by The National Institute of Health (NIH) of USA and West African International Center of Excellence for Malaria Research (ICEMR): NIAID U19 AI 089,696 was based on Research Program—Cooperative Agreements (U19) Project # 1U19AI129387-01.The work of M.F. was partially supported by MTM2016-76969-P (Spanish State Research Agency, AEI) and cofunded by the European Regional Development Fund (ERDF).
Funding Information:
Acknowledgments: We would like to thank the Fogarty International Center of the National Institutes of Health of the United States for supporting Francois Ateba under grant D43TW008652 and the West African International Center of Excellence in Malaria Research (ICEMR) for supporting his works under grants U19 AI 089696 and U19 AI 129387. The work by Manuel Febrero-Bande was partially supported by projects MTM2016-76969-P from the Spanish Ministry of Science and Innovation and European Regional Development Fund, project 10MDS207015PR from Dirección Xeral de I+D, Xunta de Galicia, and IAP network StUDyS from Belgian Science Policy. We thank all volunteers from the Mali sites who participated in these studies, all investigators for providing the data, and the data management staff for managing and extracting the data. We thank Cheick Sekou Fantamadi Traoré, Thiam Mbaye Sibe, and Mathias Dolo from Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako who worked on all aspects of this study and supported teams from the different study sites.
Funding Information:
The project at the base of the study used in this work was supported by The National Institute of Health (NIH) of USA and West African International Center of Excellence for Malaria Research (ICEMR): NIAID U19 AI 089,696 was based on Research Program?Cooperative Agreements (U19) Project # 1U19AI129387-01.The work of M.F. was partially supported by MTM2016-76969-P (Spanish State Research Agency, AEI) and cofunded by the European Regional Development Fund (ERDF).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020
Y1 - 2020
N2 - Mali aims to reach the pre-elimination stage of malaria by the next decade. This study used functional regression models to predict the incidence of malaria as a function of past meteorological patterns to better prevent and to act proactively against impending malaria outbreaks. All data were collected over a five-year period (2012–2017) from 1400 persons who sought treatment at Dangassa’s community health center. Rainfall, temperature, humidity, and wind speed variables were collected. Functional Generalized Spectral Additive Model (FGSAM), Functional Generalized Linear Model (FGLM), and Functional Generalized Kernel Additive Model (FGKAM) were used to predict malaria incidence as a function of the pattern of meteorological indicators over a continuum of the 18 weeks preceding the week of interest. Their respective outcomes were compared in terms of predictive abilities. The results showed that (1) the highest malaria incidence rate occurred in the village 10 to 12 weeks after we observed a pattern of air humidity levels >65%, combined with two or more consecutive rain episodes and a mean wind speed <1.8 m/s; (2) among the three models, the FGLM obtained the best results in terms of prediction; and (3) FGSAM was shown to be a good compromise between FGLM and FGKAM in terms of flexibility and simplicity. The models showed that some meteorological conditions may provide a basis for detection of future outbreaks of malaria. The models developed in this paper are useful for implementing preventive strategies using past meteorological and past malaria incidence.
AB - Mali aims to reach the pre-elimination stage of malaria by the next decade. This study used functional regression models to predict the incidence of malaria as a function of past meteorological patterns to better prevent and to act proactively against impending malaria outbreaks. All data were collected over a five-year period (2012–2017) from 1400 persons who sought treatment at Dangassa’s community health center. Rainfall, temperature, humidity, and wind speed variables were collected. Functional Generalized Spectral Additive Model (FGSAM), Functional Generalized Linear Model (FGLM), and Functional Generalized Kernel Additive Model (FGKAM) were used to predict malaria incidence as a function of the pattern of meteorological indicators over a continuum of the 18 weeks preceding the week of interest. Their respective outcomes were compared in terms of predictive abilities. The results showed that (1) the highest malaria incidence rate occurred in the village 10 to 12 weeks after we observed a pattern of air humidity levels >65%, combined with two or more consecutive rain episodes and a mean wind speed <1.8 m/s; (2) among the three models, the FGLM obtained the best results in terms of prediction; and (3) FGSAM was shown to be a good compromise between FGLM and FGKAM in terms of flexibility and simplicity. The models showed that some meteorological conditions may provide a basis for detection of future outbreaks of malaria. The models developed in this paper are useful for implementing preventive strategies using past meteorological and past malaria incidence.
KW - Functional model
KW - Malaria
KW - Mali
KW - Meteorological indicators
KW - Passive case detection
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U2 - 10.3390/ijerph17176339
DO - 10.3390/ijerph17176339
M3 - Article
C2 - 32878174
AN - SCOPUS:85090043503
VL - 17
SP - 1
EP - 16
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 17
M1 - 6339
ER -