TY - JOUR
T1 - Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI
AU - Jiang, Shanshan
AU - Zou, Tianyu
AU - Eberhart, Charles G.
AU - Villalobos, Maria A.V.
AU - Heo, Hye Young
AU - Zhang, Yi
AU - Wang, Yu
AU - Wang, Xianlong
AU - Yu, Hao
AU - Du, Yongxing
AU - van Zijl, Peter C.M.
AU - Wen, Zhibo
AU - Zhou, Jinyuan
N1 - Publisher Copyright:
© 2017 International Society for Magnetic Resonance in Medicine
PY - 2017/9
Y1 - 2017/9
N2 - Purpose: To assess the amide proton transfer-weighted (APTw) MRI features of isocitrate dehydrogenase (IDH)-wildtype and IDH-mutant grade II gliomas and to test the hypothesis that the APTw signal is a surrogate imaging marker for identifying IDH mutation status preoperatively. Methods: Twenty-seven patients with pathologically confirmed low-grade glioma, who were previously scanned at 3T, were retrospectively analyzed. The Mann-Whitney test was used to evaluate relationships between APTw intensities for IDH-mutant and IDH-wildtype groups, and receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance of APTw. Results: Based on histopathology and molecular analysis, seven cases were diagnosed as IDH-wildtype grade II gliomas and 20 cases as IDH-mutant grade II gliomas. The maximum and minimum APTw values, based on multiple regions of interest, as well as the whole-tumor histogram-based mean and 50th percentile APTw values, were significantly higher in the IDH-wildtype gliomas than in the IDH-mutant groups. This corresponded to the areas under the ROC curves of 0.89, 0.76, 0.75, and 0.75, respectively, for the prediction of the IDH mutation status. Conclusion: IDH-wildtype lesions typically were associated with relatively high APTw signal intensities as compared with IDH-mutant lesions. The APTw signal could be a valuable imaging biomarker by which to identify IDH1 mutation status in grade II gliomas. Magn Reson Med 78:1100–1109, 2017.
AB - Purpose: To assess the amide proton transfer-weighted (APTw) MRI features of isocitrate dehydrogenase (IDH)-wildtype and IDH-mutant grade II gliomas and to test the hypothesis that the APTw signal is a surrogate imaging marker for identifying IDH mutation status preoperatively. Methods: Twenty-seven patients with pathologically confirmed low-grade glioma, who were previously scanned at 3T, were retrospectively analyzed. The Mann-Whitney test was used to evaluate relationships between APTw intensities for IDH-mutant and IDH-wildtype groups, and receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance of APTw. Results: Based on histopathology and molecular analysis, seven cases were diagnosed as IDH-wildtype grade II gliomas and 20 cases as IDH-mutant grade II gliomas. The maximum and minimum APTw values, based on multiple regions of interest, as well as the whole-tumor histogram-based mean and 50th percentile APTw values, were significantly higher in the IDH-wildtype gliomas than in the IDH-mutant groups. This corresponded to the areas under the ROC curves of 0.89, 0.76, 0.75, and 0.75, respectively, for the prediction of the IDH mutation status. Conclusion: IDH-wildtype lesions typically were associated with relatively high APTw signal intensities as compared with IDH-mutant lesions. The APTw signal could be a valuable imaging biomarker by which to identify IDH1 mutation status in grade II gliomas. Magn Reson Med 78:1100–1109, 2017.
KW - CEST
KW - IDH
KW - amide proton transfer imaging-weighted
KW - glioma
KW - imaging biomarker
UR - http://www.scopus.com/inward/record.url?scp=85024387577&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024387577&partnerID=8YFLogxK
U2 - 10.1002/mrm.26820
DO - 10.1002/mrm.26820
M3 - Article
C2 - 28714279
AN - SCOPUS:85024387577
SN - 0740-3194
VL - 78
SP - 1100
EP - 1109
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 3
ER -