TY - JOUR
T1 - Predicting future asthma morbidity in preschool inner-city children
AU - Hansel, Nadia N.
AU - Matsui, Elizabeth C.
AU - Rusher, Robert
AU - McCormack, Meredith C.
AU - Curtin-Brosnan, Jean
AU - Peng, Roger D.
AU - Mazique, Derek
AU - Breysse, Patrick N.
AU - Diette, Gregory B.
N1 - Funding Information:
The study was supported by grants from the US Environmental Protection Agency (R82672401), NIEHS (ES09606), and NHLBI (HL04266, HL076322, and HL67850). None of the authors has any financial, consulting, or personal relationship with other people or organizations that could have influenced the work described in this article.
PY - 2011/10
Y1 - 2011/10
N2 - Background and aims: Children living in the inner city are particularly vulnerable to asthma. While we know much about factors that affect near-term outcomes in inner-city children, there is little evidence to guide clinicians on what to expect in the coming years, especially in preschool children. The purpose of our study was to determine which clinical and environmental factors are predictive of poor long-term asthma control in preschool inner-city children. Materials and methods: Baseline characteristics determined to be potential predictors of asthma severity were examined: demographics, asthma symptoms, medication use, healthcare utilization, early life medical history, family history, allergen exposure and allergic disease, and pollutant exposure. Bivariate and multivariate analyses were performed using logistic regression to examine the association of predictors of asthma severity with healthcare utilization at 2 years. Results: Of the 150 children at baseline, the follow-up rate was 83% at 2 years; therefore, 124 children were included in final analyses. At baseline, the mean age was 4.4 years and participants were predominantly African-American (90%). Most of the children were atopic and 32.5% reported using inhaled corticosteroids. Nighttime awakening from asthma and a history of pneumonia were predictive of future poor control. Conclusion: Preschool children with nighttime awakening from asthma and a history of pneumonia may deserve closer monitoring to prevent future asthma morbidity.
AB - Background and aims: Children living in the inner city are particularly vulnerable to asthma. While we know much about factors that affect near-term outcomes in inner-city children, there is little evidence to guide clinicians on what to expect in the coming years, especially in preschool children. The purpose of our study was to determine which clinical and environmental factors are predictive of poor long-term asthma control in preschool inner-city children. Materials and methods: Baseline characteristics determined to be potential predictors of asthma severity were examined: demographics, asthma symptoms, medication use, healthcare utilization, early life medical history, family history, allergen exposure and allergic disease, and pollutant exposure. Bivariate and multivariate analyses were performed using logistic regression to examine the association of predictors of asthma severity with healthcare utilization at 2 years. Results: Of the 150 children at baseline, the follow-up rate was 83% at 2 years; therefore, 124 children were included in final analyses. At baseline, the mean age was 4.4 years and participants were predominantly African-American (90%). Most of the children were atopic and 32.5% reported using inhaled corticosteroids. Nighttime awakening from asthma and a history of pneumonia were predictive of future poor control. Conclusion: Preschool children with nighttime awakening from asthma and a history of pneumonia may deserve closer monitoring to prevent future asthma morbidity.
KW - Asthma
KW - Inner city
KW - Preschool children
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U2 - 10.3109/02770903.2011.604887
DO - 10.3109/02770903.2011.604887
M3 - Article
C2 - 21861602
AN - SCOPUS:80053260940
SN - 0277-0903
VL - 48
SP - 797
EP - 803
JO - Journal of Asthma
JF - Journal of Asthma
IS - 8
ER -