@article{7e43fd68df2749938db55d2617e45fec,
title = "Predicting chance of liver transplantation for pediatric wait-list candidates",
abstract = "Information about wait-list time has been reported as one of the single most frequently asked questions by individuals awaiting a transplant but data regarding wait-list time have not been processed in a useful way for pediatric candidates. To predict chance of receiving a DDLT, we identified 6471 pediatric (<18 years), non status-1A, liver-only transplant candidates between 2006 and 2017 from the SRTR. Cox regression with shared frailty for DSA level effect was used to model the association of blood type, weight, allocation PELD and MELD, and DSA with chance of DDLT. Jackknife technique was used for validation. Median (interquartile range) wait-list time was 100 (34-309) days. Non-O Blood type, higher PELD/MELD score at listing, and DSA were associated with increased chance of DDLT, while age 1-5 years and 10-18 years was associated with lower chance of DDLT (P < 0.001 for all variables). Our model accurately predicted chance of transplant (C-statistic = 0.68) and was able to predict DDLT at specific follow-up times (eg, 3 months). This model can serve as the basis for an online tool that would provide useful information for pediatric wait-list candidates.",
keywords = "calculator, deceased donor liver transplant, pediatric, prediction",
author = "Xun Luo and Mogul, {Douglas B.} and Massie, {Allan B.} and Tanveen Ishaque and Bridges, {John F.P.} and Segev, {Dorry L.}",
note = "Funding Information: Funding information Dr Mogul is supported by grant 5K08HS023876-02 from the Agency for Healthcare Research and Quality. Dr Massie is supported by grant K01DK101677 from the National Institute of Diabetes and Digestive and Kidney Diseases. Dr Segev is supported by grants K24DK101828 and R01DK111233 from the National Institute of Diabetes and Digestive and Kidney Diseases. The data reported here have been supplied by the Minneapolis Medical Research Foundation (MMRF) as the contractor for the SRTR. The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of, or interpretation by, the SRTR or the US Government. The authors would like to acknowledge the Gilead Foundation and Larry Ackman for funding the creation of the wait-list calculator. Funding Information: Dr Mogul is supported by grant 5K08HS023876‐02 from the Agency for Healthcare Research and Quality. Dr Massie is supported by grant K01DK101677 from the National Institute of Diabetes and Digestive and Kidney Diseases. Dr Segev is supported by grants K24DK101828 and R01DK111233 from the National Institute of Diabetes and Digestive and Kidney Diseases. Funding Information: SRTR. The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of, or interpretation by, the SRTR or the US Government. The authors would like to acknowledge the Gilead Foundation and Larry Ackman for funding the creation of the wait‐ list calculator. Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = nov,
day = "1",
doi = "10.1111/petr.13542",
language = "English (US)",
volume = "23",
journal = "Pediatric Transplantation",
issn = "1397-3142",
publisher = "Wiley-Blackwell",
number = "7",
}