Predicting bleeding risk by platelet function testing in patients undergoing heart surgery

Wiktor Kuliczkowski, Joanna Sliwka, Jacek Kaczmarski, Dorota Zysko, Michal Zembala, Damian Steter, Marian Zembala, Seth Fortmann, Victor Serebruany

Research output: Contribution to journalArticle

Abstract

Background Predicting bleeding events in patients with coronary artery bypass grafting (CABG) represents an unmet medical need that may improve CABG outcomes. Hypotesis To assess the potential link between platelet function testing and bleeding risk in patients undergoing CABG. Methods Platelet aggregation and clinical outcomes in 478 patients treated with aspirin and/or clopidogrel were retrospectively analyzed. Platelet activity was assessed prior to CABG with arachidonic acid (ASPI Test), and adenosine diphosphate(ADP Test) utilizing multiple-electrode aggregometry. Results In the study group of 478 patients, mean age was 65.2±15.2 years; 138 were women. The majority of patients (n = 198) underwent on-pump surgery, with 162 undergoing off-pump and 30 undergoing minimally invasive surgery. Forty-eight patients received artificial valve implantation alone, and 40 received valve implantation in combination with CABG. The analysis of the entire pool revealed that an ASPI test value

Original languageEnglish (US)
Pages (from-to)679-683
Number of pages5
JournalClinical Cardiology
Volume38
Issue number11
DOIs
StatePublished - Nov 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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