Predicting abnormal coagulation in ischemic stroke: Reducing delay in rt-PA use

Rebecca F. Gottesman, Janice Alt, Robert J. Wityk, Rafael H. Llinas

Research output: Contribution to journalArticlepeer-review

Abstract

Normal prothrombin time (PT) and partial thromboplastin time (PTT) are recommended for administration of recombinant tissue-plasminogen activator (rt-PA) in stroke, but waiting for results can delay use. We examined the charts of 365 stroke patients to assess predetermined risk factors associated with elevated PT/PTT. Elevated PT/PTT can be predicted in patients taking warfarin or heparin/heparinoid or on hemodialysis, according to emergency department triage, with 100% sensitivity and 94.7% specificity. These results could be applied to rt-PA candidates and reduce potential delays.

Original languageEnglish (US)
Pages (from-to)1665-1667
Number of pages3
JournalNeurology
Volume67
Issue number9
DOIs
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Clinical Neurology

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