TY - GEN
T1 - Predict the neurological recovery under hypothermia after cardiac arrest using CO complexity measure of EEG signals
AU - Lu, Yueli
AU - Jiang, Dineng
AU - Jia, Xiaofeng
AU - Qiu, Yihong
AU - Zhu, Yisheng
AU - Thakor, Nitish
AU - Tong, Shanbao
PY - 2008
Y1 - 2008
N2 - Clinical trials have proven the efficacy of therapeutic hypothermia in improving the functional outcome after cardiac arrest (CA) compared with the normothermic controls. Experimental researches also demonstrated quantitative electroencephalogram (qEEG) analysis was associated with the long-term outcome of the therapeutic hypothermia in brain injury. Nevertheless, qEEG has not been able to provide a prediction earlier than 6h after the return of spontaneous circulation (ROSC). In this study, we use CO complexity to analyze the nonlinear characteristic of EEG, which could predict the neurological recovery under therapeutic hypothermia during the early phase after asphyxial cardiac arrest in rats. Twelve Wistar rats were randomly assigned to 9-min asphyxia injury under hypothermia (33°C, n=6) or normothermia (37°C, n=6). Significantly greater CO complexity was found in hypothermic group than that in normothermic group as early as 4h after the ROSC (P<0.05). CO complexity at 4h correlated well with the 72h neurodeficit score (NDS) (Pearson's correlation = 0.882). The results showed that the CO complexity could be an early predictor of the long-term neurological recovery from cardiac arrest.
AB - Clinical trials have proven the efficacy of therapeutic hypothermia in improving the functional outcome after cardiac arrest (CA) compared with the normothermic controls. Experimental researches also demonstrated quantitative electroencephalogram (qEEG) analysis was associated with the long-term outcome of the therapeutic hypothermia in brain injury. Nevertheless, qEEG has not been able to provide a prediction earlier than 6h after the return of spontaneous circulation (ROSC). In this study, we use CO complexity to analyze the nonlinear characteristic of EEG, which could predict the neurological recovery under therapeutic hypothermia during the early phase after asphyxial cardiac arrest in rats. Twelve Wistar rats were randomly assigned to 9-min asphyxia injury under hypothermia (33°C, n=6) or normothermia (37°C, n=6). Significantly greater CO complexity was found in hypothermic group than that in normothermic group as early as 4h after the ROSC (P<0.05). CO complexity at 4h correlated well with the 72h neurodeficit score (NDS) (Pearson's correlation = 0.882). The results showed that the CO complexity could be an early predictor of the long-term neurological recovery from cardiac arrest.
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M3 - Conference contribution
C2 - 19163118
AN - SCOPUS:84903875711
SN - 9781424418152
T3 - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
SP - 2133
EP - 2136
BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
T2 - 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Y2 - 20 August 2008 through 25 August 2008
ER -