Precystectomy Nomogram for Prediction of Advanced Bladder Cancer Stage{A figure is presented}

Pierre I. Karakiewicz; Shahrokh F. Shariat; Ganesh S. Palapattu; Paul Perrotte; Yair Lotan; Craig G. Rogers; Gilad E. Amiel; Amnon Vazina; Amit Gupta; Patrick J. Bastian; Arthur I. Sagalowsky; Mark Schoenberg; Seth P. Lerner

doi:10.1016/j.eururo.2006.06.010

Precystectomy Nomogram for Prediction of Advanced Bladder Cancer Stage{A figure is presented}

Pierre I. Karakiewicz, Shahrokh F. Shariat, Ganesh S. Palapattu, Paul Perrotte, Yair Lotan, Craig G. Rogers, Gilad E. Amiel, Amnon Vazina, Amit Gupta, Patrick J. Bastian, Arthur I. Sagalowsky, Mark Schoenberg, Seth P. Lerner

School of Medicine

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Objective: To evaluate precystectomy prediction of pT and pN stages at cystectomy. Methods: Multivariate logistic regression analyses modelled variables of 726 evaluable patients treated with radical cystectomy and bilateral pelvic lymphadenectomy. The first set of models predicted pT_3-4 stage at cystectomy, and the second set predicted pN_1-3 stages at cystectomy. Transurethral resection (TUR) predictors consisted of 2002 T stage, 1973 WHO tumour grade, presence of carcinoma in situ, age, gender, and delivery of neo-adjuvant chemotherapy. The area under the ROC curve quantified nomogram accuracy. Two hundred bootstrap resamples were used to reduce overfit bias. Results: At TUR, 11% of patients were staged as pT_3-4 versus 42% at cystectomy. Lymph node metastases were found in 24% of patients at cystectomy (pN_1-3). The multivariate pT_3-4 nomogram was 75.7% accurate versus 71.4% for TUR T stage. The multivariate pN_1-3 nomogram was 63.1% accurate versus 61.0% for TUR T stage. Conclusion: Multivariate nomograms are not perfect, but they do predict more accurately than TUR T stage alone.

Original language	English (US)
Pages (from-to)	1254-1262
Number of pages	9
Journal	European Urology
Volume	50
Issue number	6
DOIs	https://doi.org/10.1016/j.eururo.2006.06.010
State	Published - Dec 2006

Keywords

Bladder cancer
Cystectomy
Grade
Nomogram
Prediction
Stage

ASJC Scopus subject areas

Urology

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10.1016/j.eururo.2006.06.010

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Karakiewicz, P. I., Shariat, S. F., Palapattu, G. S., Perrotte, P., Lotan, Y., Rogers, C. G., Amiel, G. E., Vazina, A., Gupta, A., Bastian, P. J., Sagalowsky, A. I., Schoenberg, M., & Lerner, S. P. (2006). Precystectomy Nomogram for Prediction of Advanced Bladder Cancer Stage{A figure is presented}. European Urology, 50(6), 1254-1262. https://doi.org/10.1016/j.eururo.2006.06.010

@article{d6f41b85935743bf83b0a2b7c275e94a,

title = "Precystectomy Nomogram for Prediction of Advanced Bladder Cancer Stage{A figure is presented}",

abstract = "Objective: To evaluate precystectomy prediction of pT and pN stages at cystectomy. Methods: Multivariate logistic regression analyses modelled variables of 726 evaluable patients treated with radical cystectomy and bilateral pelvic lymphadenectomy. The first set of models predicted pT3-4 stage at cystectomy, and the second set predicted pN1-3 stages at cystectomy. Transurethral resection (TUR) predictors consisted of 2002 T stage, 1973 WHO tumour grade, presence of carcinoma in situ, age, gender, and delivery of neo-adjuvant chemotherapy. The area under the ROC curve quantified nomogram accuracy. Two hundred bootstrap resamples were used to reduce overfit bias. Results: At TUR, 11% of patients were staged as pT3-4 versus 42% at cystectomy. Lymph node metastases were found in 24% of patients at cystectomy (pN1-3). The multivariate pT3-4 nomogram was 75.7% accurate versus 71.4% for TUR T stage. The multivariate pN1-3 nomogram was 63.1% accurate versus 61.0% for TUR T stage. Conclusion: Multivariate nomograms are not perfect, but they do predict more accurately than TUR T stage alone.",

keywords = "Bladder cancer, Cystectomy, Grade, Nomogram, Prediction, Stage",

author = "Karakiewicz, {Pierre I.} and Shariat, {Shahrokh F.} and Palapattu, {Ganesh S.} and Paul Perrotte and Yair Lotan and Rogers, {Craig G.} and Amiel, {Gilad E.} and Amnon Vazina and Amit Gupta and Bastian, {Patrick J.} and Sagalowsky, {Arthur I.} and Mark Schoenberg and Lerner, {Seth P.}",

note = "Funding Information: PI Karakiewicz is partially supported by Fonds de la Recherche en Sant{\'e} du Qu{\'e}bec, the CHUM Foundation, the Department of Surgery and Les Urologues Associ{\'e}s du CHUM. SF Shariat is supported by the Austrian Program for Advanced Research and Treatment. GE Amiel and A Vazina are supported by the Lynn and Deanna Monical Fellowship in Urologic Oncology and Minimally Invasive Surgery.",

year = "2006",

month = dec,

doi = "10.1016/j.eururo.2006.06.010",

language = "English (US)",

volume = "50",

pages = "1254--1262",

journal = "European Urology",

issn = "0302-2838",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Precystectomy Nomogram for Prediction of Advanced Bladder Cancer Stage{A figure is presented}

AU - Karakiewicz, Pierre I.

AU - Shariat, Shahrokh F.

AU - Palapattu, Ganesh S.

AU - Perrotte, Paul

AU - Lotan, Yair

AU - Rogers, Craig G.

AU - Amiel, Gilad E.

AU - Vazina, Amnon

AU - Gupta, Amit

AU - Bastian, Patrick J.

AU - Sagalowsky, Arthur I.

AU - Schoenberg, Mark

AU - Lerner, Seth P.

N1 - Funding Information: PI Karakiewicz is partially supported by Fonds de la Recherche en Santé du Québec, the CHUM Foundation, the Department of Surgery and Les Urologues Associés du CHUM. SF Shariat is supported by the Austrian Program for Advanced Research and Treatment. GE Amiel and A Vazina are supported by the Lynn and Deanna Monical Fellowship in Urologic Oncology and Minimally Invasive Surgery.

PY - 2006/12

Y1 - 2006/12

N2 - Objective: To evaluate precystectomy prediction of pT and pN stages at cystectomy. Methods: Multivariate logistic regression analyses modelled variables of 726 evaluable patients treated with radical cystectomy and bilateral pelvic lymphadenectomy. The first set of models predicted pT3-4 stage at cystectomy, and the second set predicted pN1-3 stages at cystectomy. Transurethral resection (TUR) predictors consisted of 2002 T stage, 1973 WHO tumour grade, presence of carcinoma in situ, age, gender, and delivery of neo-adjuvant chemotherapy. The area under the ROC curve quantified nomogram accuracy. Two hundred bootstrap resamples were used to reduce overfit bias. Results: At TUR, 11% of patients were staged as pT3-4 versus 42% at cystectomy. Lymph node metastases were found in 24% of patients at cystectomy (pN1-3). The multivariate pT3-4 nomogram was 75.7% accurate versus 71.4% for TUR T stage. The multivariate pN1-3 nomogram was 63.1% accurate versus 61.0% for TUR T stage. Conclusion: Multivariate nomograms are not perfect, but they do predict more accurately than TUR T stage alone.

AB - Objective: To evaluate precystectomy prediction of pT and pN stages at cystectomy. Methods: Multivariate logistic regression analyses modelled variables of 726 evaluable patients treated with radical cystectomy and bilateral pelvic lymphadenectomy. The first set of models predicted pT3-4 stage at cystectomy, and the second set predicted pN1-3 stages at cystectomy. Transurethral resection (TUR) predictors consisted of 2002 T stage, 1973 WHO tumour grade, presence of carcinoma in situ, age, gender, and delivery of neo-adjuvant chemotherapy. The area under the ROC curve quantified nomogram accuracy. Two hundred bootstrap resamples were used to reduce overfit bias. Results: At TUR, 11% of patients were staged as pT3-4 versus 42% at cystectomy. Lymph node metastases were found in 24% of patients at cystectomy (pN1-3). The multivariate pT3-4 nomogram was 75.7% accurate versus 71.4% for TUR T stage. The multivariate pN1-3 nomogram was 63.1% accurate versus 61.0% for TUR T stage. Conclusion: Multivariate nomograms are not perfect, but they do predict more accurately than TUR T stage alone.

KW - Bladder cancer

KW - Cystectomy

KW - Grade

KW - Nomogram

KW - Prediction

KW - Stage

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UR - http://www.scopus.com/inward/citedby.url?scp=33750617349&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2006.06.010

DO - 10.1016/j.eururo.2006.06.010

M3 - Article

C2 - 16831511

AN - SCOPUS:33750617349

SN - 0302-2838

VL - 50

SP - 1254

EP - 1262

JO - European Urology

JF - European Urology

IS - 6

ER -

Precystectomy Nomogram for Prediction of Advanced Bladder Cancer Stage{A figure is presented}

Abstract

Keywords

ASJC Scopus subject areas

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