Precursors of endometrial and ovarian carcinoma

Robert J. Kurman, Thomas G. McConnell

Research output: Contribution to journalReview article

Abstract

This review discusses precursor lesions of endometrial and ovarian carcinoma with an emphasis on the unique molecular alterations that have led to the development of binary classification schemes for tumors of both the endometrium and ovary. While such a system is well established for endometrial carcinoma, only recently has a binary classification scheme been proposed for ovarian carcinoma. For both, the morphologic and molecular genetic-defining characteristics of their respective precursor lesions are described in detail. Furthermore, similarities and differences of the precursor lesions of specific tumors of these two genital tract organs are also addressed with a brief discussion of the clinical implications of their diagnosis.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalVirchows Archiv
Volume456
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Carcinoma precursors
  • Endometrial carcinoma
  • Endometrial intraepithelial carcinoma
  • Ovarian carcinoma
  • P53 signature
  • Tubal intraepithelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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