Precursor lesions to prostatic adenocarcinoma

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


High-grade prostatic intraepithelial neoplasia (PIN) is the one well-documented precursor to adenocarcinoma of the prostate. This review article defines both low- and high-grade PIN. Unusual variants of high-grade PIN are illustrated. Benign lesions that may be confused with high-grade PIN, including central zone histology, clear cell cribriform hyperplasia, and basal cell hyperplasia are described and illustrated. High-grade PIN is also differentiated from invasive acinar (usual) and ductal adenocarcinoma. The incidence of high-grade PIN, its relationship to carcinoma (including molecular findings), and risk of cancer on rebiopsy are covered in detail. Finally, intraductal carcinoma of the prostate, a controversial entity, is discussed and differentiated from high-grade PIN.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalVirchows Archiv
Issue number1
StatePublished - Jan 1 2009


  • Intraductal carcinoma of the prostate
  • Prostatic intraepithelial neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology


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