Precursor lesions of high-grade serous ovarian carcinoma: Morphological and molecular characteristics

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Abstract

The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs).

Original languageEnglish (US)
Article number126295
JournalJournal of Oncology
DOIs
StatePublished - 2010

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Carcinoma in Situ
Fallopian Tubes
Carcinoma
Mutation
Mortality

ASJC Scopus subject areas

  • Oncology

Cite this

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title = "Precursor lesions of high-grade serous ovarian carcinoma: Morphological and molecular characteristics",
abstract = "The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs).",
author = "Kala Visvanathan and Gross, {Amy L.} and Kurman, {Robert J} and Vang, {Russell S} and Shih, {Ie Ming}",
year = "2010",
doi = "10.1155/2010/126295",
language = "English (US)",
journal = "Journal of Oncology",
issn = "1687-8450",
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T1 - Precursor lesions of high-grade serous ovarian carcinoma

T2 - Morphological and molecular characteristics

AU - Visvanathan, Kala

AU - Gross, Amy L.

AU - Kurman, Robert J

AU - Vang, Russell S

AU - Shih, Ie Ming

PY - 2010

Y1 - 2010

N2 - The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs).

AB - The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs).

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