Preconditioning: The mitochondrial connection

Elizabeth Murphy, Charles Jr Steenbergen

Research output: Contribution to journalArticle

Abstract

Over the past decade there has been considerable progress in elucidating the signaling pathways involved in cardioprotection. Considerable recent data suggest that many of these signaling pathways converge on the mitochondria, where such pathways alter the activity of key mitochondrial proteins, leading to reduced apoptosis and necrosis. Inhibition of the mitochondrial permeability transition pore is emerging as a central mechanism in cardioprotection. This review focuses on mechanisms by which cardioprotection alters mitochondrial proteins and channels that regulate cell death and survival.

Original languageEnglish (US)
Pages (from-to)51-67
Number of pages17
JournalAnnual Review of Physiology
Volume69
DOIs
StatePublished - 2007

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Mitochondrial Proteins
Cell Survival
Mitochondria
Cell Death
Necrosis
Apoptosis
mitochondrial permeability transition pore

Keywords

  • Glycogen synthase kinase
  • Mitochondrial permeability transition
  • Protein kinase C
  • Voltage-dependent anion channel

ASJC Scopus subject areas

  • Physiology

Cite this

Preconditioning : The mitochondrial connection. / Murphy, Elizabeth; Steenbergen, Charles Jr.

In: Annual Review of Physiology, Vol. 69, 2007, p. 51-67.

Research output: Contribution to journalArticle

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