Preconceptional folate intake and malformations of the cardiac outflow tract

Kelley S. Scanlon; Charlotte Ferencz; Christopher A. Loffredo; P. David Wilson; Adolfo Correa-Villaseñor; Muin J. Khoury; Walter C. Willett; Joanne A. Boughman; Carol A. Magee; Joel I. Brenner; Catherine A. Neill; Lowell W. Perry; Gerard R. Martin; John W. Downing; Mohammed K. Mardini; Seymour I. Hepner

doi:10.1097/00001648-199801000-00019

Preconceptional folate intake and malformations of the cardiac outflow tract

Kelley S. Scanlon, Charlotte Ferencz, Christopher A. Loffredo, P. David Wilson, Adolfo Correa-Villaseñor, Muin J. Khoury, Walter C. Willett, Joanne A. Boughman, Carol A. Magee, Joel I. Brenner, Catherine A. Neill, Lowell W. Perry, Gerard R. Martin, John W. Downing, Mohammed K. Mardini, Seymour I. Hepner

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107 Scopus citations

Abstract

We compared cases with outflow tract defects (N = 126) with controls representative of the same birth cohort (N = 679). Infants with clinically recognized syndromes were excluded. Daily total maternal folate intake of ≤245 μg was inversely related to risk of cardiac outflow tract defects among those with transposition (odds ratio estimates: 0.65, 0.78, and 0.76 with increasing quartile of daily folate intake), but positively related among those with normally related vessels (corresponding odds ratio estimates: 1.18, 1.59, and 1.68). This difference disappeared when maternal intake of supplemental folic acid of ≤400 μg compared with <400 μg was considered, excluding dietary intake [odds ratio (OR) = 1.04: 95% confidence interval (CI) = 0.5-2.2 for infants with transposition, and OR = 0.91: 95% CI = 0.5-1.8 for those without transposition of the great arteries].

Original language	English (US)
Pages (from-to)	95-98
Number of pages	4
Journal	Epidemiology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1097/00001648-199801000-00019
State	Published - Jan 1998
Externally published	Yes

Keywords

Cardiac outflow tract defects
Cardiovascular malformations
Conotruncal defects
Folate
Folic acid
Multivitamin supplements

ASJC Scopus subject areas

Epidemiology

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10.1097/00001648-199801000-00019

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Scanlon, K. S., Ferencz, C., Loffredo, C. A., Wilson, P. D., Correa-Villaseñor, A., Khoury, M. J., Willett, W. C., Boughman, J. A., Magee, C. A., Brenner, J. I., Neill, C. A., Perry, L. W., Martin, G. R., Downing, J. W., Mardini, M. K., & Hepner, S. I. (1998). Preconceptional folate intake and malformations of the cardiac outflow tract. Epidemiology, 9(1), 95-98. https://doi.org/10.1097/00001648-199801000-00019

Scanlon, KS, Ferencz, C, Loffredo, CA, Wilson, PD, Correa-Villaseñor, A, Khoury, MJ, Willett, WC, Boughman, JA, Magee, CA, Brenner, JI, Neill, CA, Perry, LW, Martin, GR, Downing, JW, Mardini, MK & Hepner, SI 1998, 'Preconceptional folate intake and malformations of the cardiac outflow tract', Epidemiology, vol. 9, no. 1, pp. 95-98. https://doi.org/10.1097/00001648-199801000-00019

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abstract = "We compared cases with outflow tract defects (N = 126) with controls representative of the same birth cohort (N = 679). Infants with clinically recognized syndromes were excluded. Daily total maternal folate intake of ≤245 μg was inversely related to risk of cardiac outflow tract defects among those with transposition (odds ratio estimates: 0.65, 0.78, and 0.76 with increasing quartile of daily folate intake), but positively related among those with normally related vessels (corresponding odds ratio estimates: 1.18, 1.59, and 1.68). This difference disappeared when maternal intake of supplemental folic acid of ≤400 μg compared with <400 μg was considered, excluding dietary intake [odds ratio (OR) = 1.04: 95% confidence interval (CI) = 0.5-2.2 for infants with transposition, and OR = 0.91: 95% CI = 0.5-1.8 for those without transposition of the great arteries].",

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author = "Scanlon, {Kelley S.} and Charlotte Ferencz and Loffredo, {Christopher A.} and Wilson, {P. David} and Adolfo Correa-Villase{\~n}or and Khoury, {Muin J.} and Willett, {Walter C.} and Boughman, {Joanne A.} and Magee, {Carol A.} and Brenner, {Joel I.} and Neill, {Catherine A.} and Perry, {Lowell W.} and Martin, {Gerard R.} and Downing, {John W.} and Mardini, {Mohammed K.} and Hepner, {Seymour I.}",

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AU - Scanlon, Kelley S.

AU - Ferencz, Charlotte

AU - Loffredo, Christopher A.

AU - Wilson, P. David

AU - Correa-Villaseñor, Adolfo

AU - Khoury, Muin J.

AU - Willett, Walter C.

AU - Boughman, Joanne A.

AU - Magee, Carol A.

AU - Brenner, Joel I.

AU - Neill, Catherine A.

AU - Perry, Lowell W.

AU - Martin, Gerard R.

AU - Downing, John W.

AU - Mardini, Mohammed K.

AU - Hepner, Seymour I.

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Y1 - 1998/1

N2 - We compared cases with outflow tract defects (N = 126) with controls representative of the same birth cohort (N = 679). Infants with clinically recognized syndromes were excluded. Daily total maternal folate intake of ≤245 μg was inversely related to risk of cardiac outflow tract defects among those with transposition (odds ratio estimates: 0.65, 0.78, and 0.76 with increasing quartile of daily folate intake), but positively related among those with normally related vessels (corresponding odds ratio estimates: 1.18, 1.59, and 1.68). This difference disappeared when maternal intake of supplemental folic acid of ≤400 μg compared with <400 μg was considered, excluding dietary intake [odds ratio (OR) = 1.04: 95% confidence interval (CI) = 0.5-2.2 for infants with transposition, and OR = 0.91: 95% CI = 0.5-1.8 for those without transposition of the great arteries].

AB - We compared cases with outflow tract defects (N = 126) with controls representative of the same birth cohort (N = 679). Infants with clinically recognized syndromes were excluded. Daily total maternal folate intake of ≤245 μg was inversely related to risk of cardiac outflow tract defects among those with transposition (odds ratio estimates: 0.65, 0.78, and 0.76 with increasing quartile of daily folate intake), but positively related among those with normally related vessels (corresponding odds ratio estimates: 1.18, 1.59, and 1.68). This difference disappeared when maternal intake of supplemental folic acid of ≤400 μg compared with <400 μg was considered, excluding dietary intake [odds ratio (OR) = 1.04: 95% confidence interval (CI) = 0.5-2.2 for infants with transposition, and OR = 0.91: 95% CI = 0.5-1.8 for those without transposition of the great arteries].

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Preconceptional folate intake and malformations of the cardiac outflow tract

Abstract

Keywords

ASJC Scopus subject areas

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