TY - JOUR
T1 - Preconception serum DDT and pregnancy loss
T2 - A prospective study using a biomarker of pregnancy
AU - Venners, Scott A.
AU - Korrick, Susan
AU - Xu, Xiping
AU - Chen, Changzhong
AU - Guang, Wenwei
AU - Huang, Aiqun
AU - Altshul, Larisa
AU - Perry, Melissa
AU - Fu, Lingling
AU - Wang, Xiaobin
N1 - Funding Information:
This study is supported in part by grant 1R01 HD32505 from the National Institute of Child Health and Human Development; grants 1R01 ES08337, ES-00002, P01 ES06198, K01 ES12052, 1R01 ES008957, and 1R01 ES11682 from the National Institute of Environmental Health Sciences; and grants 20-FY98-0701 and 20-FY02-56 from the US March of Dimes Birth Defects Foundation. Conflict of interest: none declared.
PY - 2005/10
Y1 - 2005/10
N2 - Previous studies of pregnancy losses and 1,1,1-trichloro-2,2-bis(p- chlorophenyl)ethane (DDT) were limited because they did not include losses prior to clinical detection of pregnancy and because exposures were measured after the pregnancies of interest. The authors examined the association of preconception serum total DDT (sum of DDT isomers and metabolites) concentration and subsequent pregnancy losses in 388 newly married, nonsmoking, female textile workers in China between 1996 and 1998. Upon stopping contraception, subjects provided daily urine specimens and records of vaginal bleeding for up to 1 year or until clinical pregnancy. Daily urinary human chorionic gonadotropin was assayed to detect conception and early pregnancy losses, and pregnancies were followed to detect clinical spontaneous abortions. There were 128 (26%) early pregnancy losses in 500 conceptions and 36 (10%) spontaneous abortions in 372 clinical pregnancies. Subjects were grouped in tertiles by preconception serum total DDT concentration (group 1: 5.5-22.9 ng/g; group 2: 23.0-36.5 ng/g; group 3: 36.6-113.3 ng/g). Compared with group 1, group 2 had adjusted relative odds of early pregnancy losses of 1.23 (95% confidence interval (CI): 0.72, 2.10), and group 3 had adjusted odds of 2.12 (95% CI: 1.26, 3.57). The relative odds of early pregnancy losses associated with a 10-ng/g increase in serum total DDT were 1.17 (95% CI: 1.05, 1.29). The small number of spontaneous abortions following clinical detection of pregnancy were not associated with serum total DDT. In this population, there was a positive, monotonic, exposure-response association between preconception serum total DDT and the risk of subsequent early pregnancy losses.
AB - Previous studies of pregnancy losses and 1,1,1-trichloro-2,2-bis(p- chlorophenyl)ethane (DDT) were limited because they did not include losses prior to clinical detection of pregnancy and because exposures were measured after the pregnancies of interest. The authors examined the association of preconception serum total DDT (sum of DDT isomers and metabolites) concentration and subsequent pregnancy losses in 388 newly married, nonsmoking, female textile workers in China between 1996 and 1998. Upon stopping contraception, subjects provided daily urine specimens and records of vaginal bleeding for up to 1 year or until clinical pregnancy. Daily urinary human chorionic gonadotropin was assayed to detect conception and early pregnancy losses, and pregnancies were followed to detect clinical spontaneous abortions. There were 128 (26%) early pregnancy losses in 500 conceptions and 36 (10%) spontaneous abortions in 372 clinical pregnancies. Subjects were grouped in tertiles by preconception serum total DDT concentration (group 1: 5.5-22.9 ng/g; group 2: 23.0-36.5 ng/g; group 3: 36.6-113.3 ng/g). Compared with group 1, group 2 had adjusted relative odds of early pregnancy losses of 1.23 (95% confidence interval (CI): 0.72, 2.10), and group 3 had adjusted odds of 2.12 (95% CI: 1.26, 3.57). The relative odds of early pregnancy losses associated with a 10-ng/g increase in serum total DDT were 1.17 (95% CI: 1.05, 1.29). The small number of spontaneous abortions following clinical detection of pregnancy were not associated with serum total DDT. In this population, there was a positive, monotonic, exposure-response association between preconception serum total DDT and the risk of subsequent early pregnancy losses.
KW - Abortion, spontaneous
KW - Chorionic gonadotropin
KW - DDT
KW - Dichlorodiphenyl dichloroethylene
KW - Dichlorodiphenyldichloroethane
KW - Hormone antagonists
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U2 - 10.1093/aje/kwi275
DO - 10.1093/aje/kwi275
M3 - Article
C2 - 16120699
AN - SCOPUS:26444512219
SN - 0002-9262
VL - 162
SP - 709
EP - 716
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 8
ER -