Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women

Alayne G. Ronnenberg, Richard J. Wood, Xiaobin Wang, Houxun Xing, Chanzhong Chen, Dafang Chen, Wenwei Guang, Aiqun Huang, Lihua Wang, Xiping Xu

Research output: Contribution to journalArticle

Abstract

Prenatal anemia and iron deficiency are associated with adverse birth outcomes, but no previous studies have examined the relation between preconception anemia, iron deficiency, and pregnancy outcome in healthy women. We measured hemoglobin (Hb), ferritin, transferrin receptor (TfR), and vitamins B-6, B-12, and folate concentrations before pregnancy in 405 Chinese women (median time from sample collection to gestation end = 316 d). Both mild (95 ≤ Hb <120 g/L) and moderate (Hb <95 g/L) anemia were significantly associated with lower birthweight (139 and 192 g, respectively); iron-deficiency anemia alone (Hb <120 g, ferritin <12 μg/L, no B-vitamin deficiency) was associated with a 242-g decrease in birthweight. Both low (

Original languageEnglish (US)
Pages (from-to)2586-2591
Number of pages6
JournalJournal of Nutrition
Volume134
Issue number10
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

pregnancy outcome
ferritin
Pregnancy Outcome
Ferritins
Iron-Deficiency Anemias
hemoglobin
Hemoglobins
iron deficiency anemia
anemia
vitamin B deficiency
Vitamin B Deficiency
pregnancy
Pregnancy
Vitamin B 6
Transferrin Receptors
low birth weight
transferrin
pyridoxine
Transferrin
Folic Acid

Keywords

  • Anemia
  • China
  • Ferritin
  • Pregnancy
  • Transferrin receptor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women. / Ronnenberg, Alayne G.; Wood, Richard J.; Wang, Xiaobin; Xing, Houxun; Chen, Chanzhong; Chen, Dafang; Guang, Wenwei; Huang, Aiqun; Wang, Lihua; Xu, Xiping.

In: Journal of Nutrition, Vol. 134, No. 10, 10.2004, p. 2586-2591.

Research output: Contribution to journalArticle

Ronnenberg, AG, Wood, RJ, Wang, X, Xing, H, Chen, C, Chen, D, Guang, W, Huang, A, Wang, L & Xu, X 2004, 'Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women', Journal of Nutrition, vol. 134, no. 10, pp. 2586-2591.
Ronnenberg, Alayne G. ; Wood, Richard J. ; Wang, Xiaobin ; Xing, Houxun ; Chen, Chanzhong ; Chen, Dafang ; Guang, Wenwei ; Huang, Aiqun ; Wang, Lihua ; Xu, Xiping. / Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women. In: Journal of Nutrition. 2004 ; Vol. 134, No. 10. pp. 2586-2591.
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