Precocious puberty in a boy with hepatoma and circulating gonadotropin

W. Hung; R. M. Blizzard; C. J. Migeon; A. M. Camacho; W. L. Nyhan

doi:10.1016/S0022-3476(63)80220-6

Precocious puberty in a boy with hepatoma and circulating gonadotropin

W. Hung, R. M. Blizzard, C. J. Migeon, A. M. Camacho, W. L. Nyhan

School of Medicine

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Sexual precocity resulting from circulating gonadotropin is reported in a 2-year-old child with hepatoblastoma. Following removal of the tumor the sexual precocity regressed and the gonadotropin in the serum disappeared. The patient eventually succumbed to his disease as have the other four similar patients that have been reported upon. This unusual cause of sexual precocity must be considered in the differential diagnosis of isosexual precocity. The clinical signs and symptoms, and the chemical abnormalities that occur in patients of this type, are discussed.

Original language	English (US)
Pages (from-to)	895-903
Number of pages	9
Journal	The Journal of pediatrics
Volume	63
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(63)80220-6
State	Published - Nov 1963

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(63)80220-6

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title = "Precocious puberty in a boy with hepatoma and circulating gonadotropin",

abstract = "Sexual precocity resulting from circulating gonadotropin is reported in a 2-year-old child with hepatoblastoma. Following removal of the tumor the sexual precocity regressed and the gonadotropin in the serum disappeared. The patient eventually succumbed to his disease as have the other four similar patients that have been reported upon. This unusual cause of sexual precocity must be considered in the differential diagnosis of isosexual precocity. The clinical signs and symptoms, and the chemical abnormalities that occur in patients of this type, are discussed.",

author = "W. Hung and Blizzard, {R. M.} and Migeon, {C. J.} and Camacho, {A. M.} and Nyhan, {W. L.}",

note = "Funding Information: From The Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Md. This work was supported by Research Grants \[rom the United States Public Health Service. Dr. Hung was a trainee sponsored by Traineeship Grant No. 2 A-5219, United States Public Health Service. Dr. Nyhan is a Faculty Research Associate o\[ The American Cancer Society.",

year = "1963",

month = nov,

doi = "10.1016/S0022-3476(63)80220-6",

language = "English (US)",

volume = "63",

pages = "895--903",

journal = "The Journal of pediatrics",

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TY - JOUR

T1 - Precocious puberty in a boy with hepatoma and circulating gonadotropin

AU - Hung, W.

AU - Blizzard, R. M.

AU - Migeon, C. J.

AU - Camacho, A. M.

AU - Nyhan, W. L.

N1 - Funding Information: From The Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Md. This work was supported by Research Grants \[rom the United States Public Health Service. Dr. Hung was a trainee sponsored by Traineeship Grant No. 2 A-5219, United States Public Health Service. Dr. Nyhan is a Faculty Research Associate o\[ The American Cancer Society.

PY - 1963/11

Y1 - 1963/11

N2 - Sexual precocity resulting from circulating gonadotropin is reported in a 2-year-old child with hepatoblastoma. Following removal of the tumor the sexual precocity regressed and the gonadotropin in the serum disappeared. The patient eventually succumbed to his disease as have the other four similar patients that have been reported upon. This unusual cause of sexual precocity must be considered in the differential diagnosis of isosexual precocity. The clinical signs and symptoms, and the chemical abnormalities that occur in patients of this type, are discussed.

AB - Sexual precocity resulting from circulating gonadotropin is reported in a 2-year-old child with hepatoblastoma. Following removal of the tumor the sexual precocity regressed and the gonadotropin in the serum disappeared. The patient eventually succumbed to his disease as have the other four similar patients that have been reported upon. This unusual cause of sexual precocity must be considered in the differential diagnosis of isosexual precocity. The clinical signs and symptoms, and the chemical abnormalities that occur in patients of this type, are discussed.

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Precocious puberty in a boy with hepatoma and circulating gonadotropin

Abstract

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