Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole

Toward first in human studies

Ellen E. Codd, Hanna H. Ng, Claire McFarlane, Edward S. Riccio, Rupa Doppalapudi, Jon C. Mirsalis, R. John Horton, Armandoe Gonzalez, H. Hugo Garcia, Robert H Gilman

Research output: Contribution to journalArticle

Abstract

A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses than did males. Decreased white blood cell levels, a class effect of benzimidazole anthelmintics, returned to normal during the recovery period. The no observed adverse effect level was determined to be >5 but

Original languageEnglish (US)
Pages (from-to)129-137
Number of pages9
JournalInternational Journal of Toxicology
Volume34
Issue number2
DOIs
StatePublished - Mar 10 2015

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Pharmacokinetics
Toxicology
Toxicity
Rats
Safety
No-Observed-Adverse-Effect Level
Thymus
Anthelmintics
Epididymis
Liver
Thymus Gland
Testis
Bone
Leukocytes
Blood
Spleen
Bone Marrow
Cells
Recovery
oxfendazole

Keywords

  • anthelmintic
  • benzimidazole
  • cysticercosis
  • soil-transmitted helminths

ASJC Scopus subject areas

  • Toxicology

Cite this

Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole : Toward first in human studies. / Codd, Ellen E.; Ng, Hanna H.; McFarlane, Claire; Riccio, Edward S.; Doppalapudi, Rupa; Mirsalis, Jon C.; Horton, R. John; Gonzalez, Armandoe; Garcia, H. Hugo; Gilman, Robert H.

In: International Journal of Toxicology, Vol. 34, No. 2, 10.03.2015, p. 129-137.

Research output: Contribution to journalArticle

Codd, Ellen E. ; Ng, Hanna H. ; McFarlane, Claire ; Riccio, Edward S. ; Doppalapudi, Rupa ; Mirsalis, Jon C. ; Horton, R. John ; Gonzalez, Armandoe ; Garcia, H. Hugo ; Gilman, Robert H. / Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole : Toward first in human studies. In: International Journal of Toxicology. 2015 ; Vol. 34, No. 2. pp. 129-137.
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