Preclinical studies of gossypol in prostate carcinoma

H. R. Naik, D. Petrylak, A. Yagoda, J. E. Lehr, A. Akhtar, K. J. Pienta

Research output: Contribution to journalArticlepeer-review

Abstract

Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vivo, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalInternational journal of oncology
Volume6
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • gossypol
  • prostate neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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