Preclinical studies of gossypol in prostate carcinoma

H. R. Naik, D. Petrylak, A. Yagoda, J. E. Lehr, A. Akhtar, Kenneth Pienta

Research output: Contribution to journalArticle

Abstract

Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vivo, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalInternational Journal of Oncology
Volume6
Issue number1
StatePublished - 1995
Externally publishedYes

Fingerprint

Gossypol
Prostate
Carcinoma
Prostatic Neoplasms
Hormones
Cottonseed Oil
Cell Line
Growth
Adenocarcinoma
Neoplasms

Keywords

  • gossypol
  • prostate neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Naik, H. R., Petrylak, D., Yagoda, A., Lehr, J. E., Akhtar, A., & Pienta, K. (1995). Preclinical studies of gossypol in prostate carcinoma. International Journal of Oncology, 6(1), 209-213.

Preclinical studies of gossypol in prostate carcinoma. / Naik, H. R.; Petrylak, D.; Yagoda, A.; Lehr, J. E.; Akhtar, A.; Pienta, Kenneth.

In: International Journal of Oncology, Vol. 6, No. 1, 1995, p. 209-213.

Research output: Contribution to journalArticle

Naik, HR, Petrylak, D, Yagoda, A, Lehr, JE, Akhtar, A & Pienta, K 1995, 'Preclinical studies of gossypol in prostate carcinoma', International Journal of Oncology, vol. 6, no. 1, pp. 209-213.
Naik HR, Petrylak D, Yagoda A, Lehr JE, Akhtar A, Pienta K. Preclinical studies of gossypol in prostate carcinoma. International Journal of Oncology. 1995;6(1):209-213.
Naik, H. R. ; Petrylak, D. ; Yagoda, A. ; Lehr, J. E. ; Akhtar, A. ; Pienta, Kenneth. / Preclinical studies of gossypol in prostate carcinoma. In: International Journal of Oncology. 1995 ; Vol. 6, No. 1. pp. 209-213.
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