Preclinical studies of gossypol in prostate carcinoma

H. R. Naik; D. Petrylak; A. Yagoda; J. E. Lehr; A. Akhtar; K. J. Pienta

doi:10.3892/ijo.6.1.209

Preclinical studies of gossypol in prostate carcinoma

H. R. Naik, D. Petrylak, A. Yagoda, J. E. Lehr, A. Akhtar, K. J. Pienta

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vivo, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.

Original language	English (US)
Pages (from-to)	209-213
Number of pages	5
Journal	International journal of oncology
Volume	6
Issue number	1
DOIs	https://doi.org/10.3892/ijo.6.1.209
State	Published - 1995
Externally published	Yes

Keywords

gossypol
prostate neoplasms

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3892/ijo.6.1.209

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AU - Naik, H. R.

AU - Petrylak, D.

AU - Yagoda, A.

AU - Lehr, J. E.

AU - Akhtar, A.

AU - Pienta, K. J.

PY - 1995

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AB - Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vivo, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.

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Preclinical studies of gossypol in prostate carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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