Preclinical MRI-Guided Focused Ultrasound: A Review of Systems and Current Practices

Nicholas P.K. Ellens; Ari Partanen

doi:10.1109/TUFFC.2016.2609238

Preclinical MRI-Guided Focused Ultrasound: A Review of Systems and Current Practices

Nicholas P.K. Ellens, Ari Partanen

School of Medicine

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Effective preclinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review, we seek to outline the challenges at hand for effective preclinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated preclinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research. Specifically, we examine additional hardware that has been used to adapt clinical MRgFUS equipment to better position, constrain, and image preclinical subjects, as well as software solutions that have been used to extend the potential and capabilities of clinical devices.

Original language	English (US)
Pages (from-to)	291-305
Number of pages	15
Journal	IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume	64
Issue number	1
DOIs	https://doi.org/10.1109/TUFFC.2016.2609238
State	Published - Jan 2017

Keywords

Biomedical applications of radiation
biomedical transducers
ultrasonic transducers

ASJC Scopus subject areas

Instrumentation
Acoustics and Ultrasonics
Electrical and Electronic Engineering

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10.1109/TUFFC.2016.2609238

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Preclinical MRI-Guided Focused Ultrasound: A Review of Systems and Current Practices

Abstract

Keywords

ASJC Scopus subject areas

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