@article{e4c9248f0b6547278a412ab72bf0d80d,
title = "Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions",
abstract = "As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.",
keywords = "United States Department of Veterans Affairs, blast-induced neurotrauma, conference, experimental models, preclinical research, traumatic brain injury",
author = "Ibolja Cernak and Stein, {Donald G.} and Elder, {Gregory A.} and Stephn Ahlers and Kenneth Curley and DePalma, {Ralph G.} and John Duda and Milos Ikonomovic and Iverson, {Grant L.} and Firas Kobeissy and Koliatsos, {Vassilis E.} and Leggieri, {Michael J.} and Pacifico, {Anthony M.} and Smith, {Douglas H.} and Raymond Swanson and Thompson, {Floyd J.} and Tortella, {Frank C.}",
note = "Funding Information: aMilitary and Veterans{\textquoteright} Clinical Rehabilitation Research, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada; bEmory School of Medicine, Department of Emergency Medicine Brain Research Laboratory, Atlanta, Georgia, USA; cJames J. Peters VA Medical Center, Bronx, NY, USA; dIcahn School of Medicine at Mount Sinai, New York, New York, USA; eOperational and Undersea Medicine, Naval Medical Research Center, Silver Spring, MD, USA; fIatrikos Research and Development Strategies, LLC, Tampa, FL, USA; gDepartment of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; hVA ORD & Department of Surgery, Uniformed Services University of the Health Sciences, Office of Research and Development, Washington, DC, USA; iParkinson{\textquoteright}s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center; and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; jDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; kNeuropsychology Outcome Assessment Laboratory, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA; lPsychoproteomics and Nanotechnology Research Center, Department of Psychiatry, The Evelyn F and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA; mDepartment of Pathology (Neuropathology) and Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA; nDoD Blast Injury Research Program Coordinating Office, U.S. Army Medical Research and Materiel Command, Ft Detrick, MD, USA; oAlzheimer{\textquoteright}s and Epilepsy Research Programs, Congressionally Directed Medical Research Programs; US Department of Health and Human Services, Telemedicine and Advanced Technology Research Center, Fort Detrick, MD, USA; pThe Robert A. Groff Professor of Neurosurgery/Research and Education, Department of Neurosurgery/PENN{\textquoteright}s Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, PA, USA; qDepartment of Neurology, University of California San Francisco; and Neurology Service, SFVAMC, San Francisco, CA, USA; rBrain Rehabilitation Research Center, Malcom Randall VAMC; Physiological Sciences and Professor Emeritus, Neuroscience, University of Florida, Gainesville, FL, USA; sBranch of Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research; Silver Spring, MD, USA Funding Information: Because of the personal and financial costs caused by TBIs/ BINTs, the US Departments of Defense (DoD) and Veterans Affairs (VA) are allocating substantial financial and intellectual support to experimental and clinical research efforts aiming at better understanding of the essential mechanisms of brain injuries and the development of novel diagnostic and treatment approaches. This funding commitment has boosted the number of experimental studies focusing on TBI and BINT. Figure 1 shows the number of articles using rat (Figure 1A) or mouse (Figure 1B) TBI or BINT models published between 2008 and the first half of 2016. The productivity of this period is considerable: approximately 5200 articles used a rat model and Funding Information: In addition to the publications as a measure of intensified research on TBI/BINT, the impressive financial support awarded by the National Institutes of Health for projects addressing any aspects of traumatic brain injury research during the 2008–2015 period further demonstrates the institutional commitment towards neurotrauma research. Indeed, over $509 M has been spent for 1,369 projects and 136 subproject addressing some aspects of TBI/BINT. Publisher Copyright: {\textcopyright} 2017 Taylor & Francis Group, LLC.",
year = "2017",
month = jul,
day = "29",
doi = "10.1080/02699052.2016.1274779",
language = "English (US)",
volume = "31",
pages = "1168--1176",
journal = "Brain Injury",
issn = "0269-9052",
publisher = "Informa Healthcare",
number = "9",
}