Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Ibolja Cernak, Donald G. Stein, Gregory A. Elder, Stephn Ahlers, Kenneth Curley, Ralph G. DePalma, John Duda, Milos Ikonomovic, Grant L. Iverson, Firas Kobeissy, Vassilis E. Koliatsos, Michael J. Leggieri, Anthony M. Pacifico, Douglas H. Smith, Raymond Swanson, Floyd J. Thompson, Frank C. Tortella

Research output: Contribution to journalArticlepeer-review

Abstract

As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.

Original languageEnglish (US)
Pages (from-to)1168-1176
Number of pages9
JournalBrain Injury
Volume31
Issue number9
DOIs
StatePublished - Jul 29 2017

Keywords

  • United States Department of Veterans Affairs
  • blast-induced neurotrauma
  • conference
  • experimental models
  • preclinical research
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology

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