TY - JOUR
T1 - Precision psychiatry with immunological and cognitive biomarkers
T2 - a multi-domain prediction for the diagnosis of bipolar disorder or schizophrenia using machine learning
AU - Fernandes, Brisa S.
AU - Karmakar, Chandan
AU - Tamouza, Ryad
AU - Tran, Truyen
AU - Yearwood, John
AU - Hamdani, Nora
AU - Laouamri, Hakim
AU - Richard, Jean Romain
AU - Yolken, Robert
AU - Berk, Michael
AU - Venkatesh, Svetha
AU - Leboyer, Marion
N1 - Funding Information:
We thank the foundation FondaMental (www.fondation-fondamental.org) which is a non profit foundation supporting research in psychiatry in France. We express all our thanks to the patients who have accepted to be included in the present study. We thank the Biological Resources Centre (Prs Bijan Galey and Caroline Barau) and the clinical Investigation center (Pr Philippe LeCorvoisier) of Mondor Hospital We thank Agence Nationale de la Recherche (ANR) (Samenta Project V.I.P. ANR-08-MNPS-041), INSERM and AP-HP. MB is supported by a NHMRC Senior Principal Research Fellowship (1059660 and 1156072).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Precision psychiatry is attracting increasing attention lately as a recognized priority. One of the goals of precision psychiatry is to develop tools capable of aiding a clinically informed psychiatric diagnosis objectively. Cognitive, inflammatory and immunological factors are altered in both bipolar disorder (BD) and schizophrenia (SZ), however, most of these alterations do not respect diagnostic boundaries from a phenomenological perspective and possess great variability in different individuals with the same phenotypic diagnosis and, consequently, none so far has proven to have the ability of reliably aiding in the differential diagnosis of BD and SZ. We developed a probabilistic multi-domain data integration model consisting of immune and inflammatory biomarkers in peripheral blood and cognitive biomarkers using machine learning to predict diagnosis of BD and SZ. A total of 416 participants, being 323, 372, and 279 subjects for blood, cognition and combined biomarkers analysis, respectively. Our multi-domain model performances for the BD vs. control (sensitivity 80% and specificity 71%) and for the SZ vs. control (sensitivity 84% and specificity 81%) pairs were high in general, however, our multi-domain model had only moderate performance for the differential diagnosis of BD and SZ (sensitivity 71% and specificity 73%). In conclusion, our results show that the diagnosis of BD and of SZ, and that the differential diagnosis of BD and SZ can be predicted with possible clinical utility by a computational machine learning algorithm employing blood and cognitive biomarkers, and that their integration in a multi-domain outperforms algorithms based in only one domain. Independent studies are needed to validate these findings.
AB - Precision psychiatry is attracting increasing attention lately as a recognized priority. One of the goals of precision psychiatry is to develop tools capable of aiding a clinically informed psychiatric diagnosis objectively. Cognitive, inflammatory and immunological factors are altered in both bipolar disorder (BD) and schizophrenia (SZ), however, most of these alterations do not respect diagnostic boundaries from a phenomenological perspective and possess great variability in different individuals with the same phenotypic diagnosis and, consequently, none so far has proven to have the ability of reliably aiding in the differential diagnosis of BD and SZ. We developed a probabilistic multi-domain data integration model consisting of immune and inflammatory biomarkers in peripheral blood and cognitive biomarkers using machine learning to predict diagnosis of BD and SZ. A total of 416 participants, being 323, 372, and 279 subjects for blood, cognition and combined biomarkers analysis, respectively. Our multi-domain model performances for the BD vs. control (sensitivity 80% and specificity 71%) and for the SZ vs. control (sensitivity 84% and specificity 81%) pairs were high in general, however, our multi-domain model had only moderate performance for the differential diagnosis of BD and SZ (sensitivity 71% and specificity 73%). In conclusion, our results show that the diagnosis of BD and of SZ, and that the differential diagnosis of BD and SZ can be predicted with possible clinical utility by a computational machine learning algorithm employing blood and cognitive biomarkers, and that their integration in a multi-domain outperforms algorithms based in only one domain. Independent studies are needed to validate these findings.
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U2 - 10.1038/s41398-020-0836-4
DO - 10.1038/s41398-020-0836-4
M3 - Article
C2 - 32448868
AN - SCOPUS:85085303845
SN - 2158-3188
VL - 10
JO - Translational psychiatry
JF - Translational psychiatry
IS - 1
M1 - 162
ER -