TY - JOUR
T1 - Precision aging
T2 - Applying precision medicine to the field of cognitive aging
AU - Ryan, Lee
AU - Hay, Meredith
AU - Huentelman, Matt J.
AU - Duarte, Audrey
AU - Rundek, Tatjana
AU - Levin, Bonnie
AU - Soldan, Anja
AU - Pettigrew, Corinne
AU - Mehl, Matthias R.
AU - Barnes, Carol A.
N1 - Publisher Copyright:
© 2019 Frontiers Media S.A. All Rights Reserved.
PY - 2019
Y1 - 2019
N2 - The current "one size fits all" approach to our cognitive aging population is not adequate to close the gap between cognitive health span and lifespan. In this review article, we present a novel model for understanding, preventing, and treating age-related cognitive impairment (ARCI) based on concepts borrowed from precision medicine. We will discuss how multiple risk factors can be classified into risk categories because of their interrelatedness in real life, the genetic variants that increase sensitivity to, or ameliorate, risk for ARCI, and the brain drivers or common mechanisms mediating brain aging. Rather than providing a definitive model of risk for ARCI and cognitive decline, the Precision Aging model is meant as a starting point to guide future research. To that end, after briefly discussing key risk categories, genetic risks, and brain drivers, we conclude with a discussion of steps that must be taken to move the field forward.
AB - The current "one size fits all" approach to our cognitive aging population is not adequate to close the gap between cognitive health span and lifespan. In this review article, we present a novel model for understanding, preventing, and treating age-related cognitive impairment (ARCI) based on concepts borrowed from precision medicine. We will discuss how multiple risk factors can be classified into risk categories because of their interrelatedness in real life, the genetic variants that increase sensitivity to, or ameliorate, risk for ARCI, and the brain drivers or common mechanisms mediating brain aging. Rather than providing a definitive model of risk for ARCI and cognitive decline, the Precision Aging model is meant as a starting point to guide future research. To that end, after briefly discussing key risk categories, genetic risks, and brain drivers, we conclude with a discussion of steps that must be taken to move the field forward.
KW - Aging
KW - Cognition
KW - Cognitive decline
KW - Cognitive impairment
KW - Risk for Alzheimer's disease
UR - http://www.scopus.com/inward/record.url?scp=85069219128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069219128&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2019.00128
DO - 10.3389/fnagi.2019.00128
M3 - Review article
C2 - 31231204
AN - SCOPUS:85069219128
SN - 1663-4365
VL - 11
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
IS - JUN
M1 - 128
ER -