Precisely defining high-risk operable head and neck tumors based on RTOG 85-03 and 88-24: Targets for postoperative radiochemotherapy?

Jay S. Cooper, Thomas F. Pajak, Arlene Forastiere, John Jacobs, Karen K. Fu, Kian K. Ang, George E. Laramore, Muhyi Al-Sarraf

Research output: Contribution to journalArticle

Abstract

Background. Local-regional recurrence of disease remains the major obstacle to cure of advanced head and neck cancers. Methods. This investigation reviewed data derived from Radiation Therapy Oncology Group (RTOG) protocols 85-03 and 88-24 to identify characteristics of tumors that predicted local-regional recurrence of disease following surgery and postoperative radiotherapy (RT). Results. The presence of tumor in two or more lymph nodes, and/or extracapsular spread of nodal disease, and/or microscopic-size tumor involvement of the surgical margins of resection imparts a high risk of local-regional (L-R) relapse. Our data also support the hypothesis that, following surgery, the concurrent addition of chemotherapy (CT) to RT may increase the likelihood of L-R control of disease for patients who have these high-risk characteristics. Conclusion. A prospective trial of surgery followed by concurrent RT and CT is warranted for patients who have high-risk characteristics found at surgery.

Original languageEnglish (US)
Pages (from-to)588-594
Number of pages7
JournalHead and Neck
Volume20
Issue number7
DOIs
StatePublished - Oct 1 1998

Keywords

  • Cancer
  • Chemotherapy
  • Head and neck
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

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