Precipitated withdrawal during maintenance opioid blockade with extended release naltrexone

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24 Scopus citations


Background: There has been increasing interest in the use of extended release injectable naltrexone for the treatment of opioid dependence. Case description: We report a case of precipitated withdrawal in a 17-year-old adolescent female receiving extended release naltrexone (Vivitrol) for opioid dependence, following her third serial monthly dose of the medication, several days after using oxycodone with mild intoxication. Conclusions: This case suggests that, in some circumstances, the opioid blockade may be overcome when naltrexone levels drop towards the end of the dosing interval, producing vulnerability to subsequent naltrexone-induced withdrawal. This may provide cautionary guidance for clinical management and dosing strategies.

Original languageEnglish (US)
Pages (from-to)1399-1401
Number of pages3
Issue number8
StatePublished - Aug 2008


  • Adolescents
  • Clinical management
  • Naltrexone
  • Opioid blockade
  • Opioid dependence
  • Vivitrol
  • Withdrawal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health


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