Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896

Richard J. Lamb, Roland R. Griffiths

Research output: Contribution to journalArticle

Abstract

In order to assess the ability of lorazepam (20 mg/kg/day) and CGS 9896 (100 mg/kg/day) to produce physical-dependence in baboons, the occurrence of Ro 15-1788 precipitated withdrawal signs and spontaneous withdrawal signs were determined. Lorazepam-treated baboons displayed precipitated withdrawal signs following the administration of Ro 15-1788 (5 mg/ kg), and displayed mild to moderate spontaneous withdrawal signs following termination of drug treatment. CGS 9896-treated baboons did not display Ro 15-1788 precipitated withdrawal signs and displayed either no or only mild spontaneous withdrawal signs.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalDrug and alcohol dependence
Volume14
Issue number1
DOIs
StatePublished - Sep 1984

Keywords

  • Baboon
  • Benzodiazepine
  • CGS 9896
  • Flumazepil
  • Lorazepam
  • Physical dependence
  • Ro 15-1788

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896'. Together they form a unique fingerprint.

  • Cite this