TY - JOUR
T1 - Precancerous lesions of the pancreas
AU - Zamboni, Giuseppe
AU - Hirabayashi, Kenichi
AU - Castelli, Paola
AU - Lennon, Anne Marie
PY - 2013/4
Y1 - 2013/4
N2 - Pancreatic cancer has a very poor prognosis, with a five year survival of only 5%. New studies have shown that it takes over 11 years for cells to develop invasive capability. This provides an opportunity to intervene if precursor lesions can be detected. This paper reviews the molecular, pathological, clinical findings and management of pancreatic intraepithelial neoplasia (PanIN), intraductal pancreatic mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN), three precursor lesions which can give rise to invasive carcinoma of the pancreas.
AB - Pancreatic cancer has a very poor prognosis, with a five year survival of only 5%. New studies have shown that it takes over 11 years for cells to develop invasive capability. This provides an opportunity to intervene if precursor lesions can be detected. This paper reviews the molecular, pathological, clinical findings and management of pancreatic intraepithelial neoplasia (PanIN), intraductal pancreatic mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN), three precursor lesions which can give rise to invasive carcinoma of the pancreas.
KW - Pancreas
KW - Pancreatic cancer
KW - Pancreatic neoplasms
KW - Pathology
KW - Precancerous lesions
UR - http://www.scopus.com/inward/record.url?scp=84879788056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879788056&partnerID=8YFLogxK
U2 - 10.1016/j.bpg.2013.04.001
DO - 10.1016/j.bpg.2013.04.001
M3 - Review article
C2 - 23809247
AN - SCOPUS:84879788056
SN - 1521-6918
VL - 27
SP - 299
EP - 322
JO - Best Practice and Research: Clinical Gastroenterology
JF - Best Practice and Research: Clinical Gastroenterology
IS - 2
ER -