Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus infection and death after kidney transplantation

Q. Sun, E. C. Hall, Y. Huang, P. Chen, K. Dibadj, M. Murawski, R. Shraybman, K. Van Kirk, V. Tang, R. Peng, P. R. Patton, M. J. Clare-Salzler, B. Kaplan, D. L. Segev, K. L. Womer

Research output: Contribution to journalArticle

Abstract

Background: Dendritic cells (DCs) are potent antigen-presenting cells critical for immunity. We previously demonstrated a significant association between pre-transplant blood myeloid dendritic cell (mDC) and plasmacytoid dendritic cell (pDC) deficiency and post-transplant BK viremia in renal transplant recipients. In the current post-hoc analysis, we studied the association of these same pre-transplant DC levels with other post-transplant outcomes. Methods: Pre-transplant peripheral blood mDC and pDC levels were quantified using flow cytometry in 78 patients undergoing kidney transplantation. Post-transplant outcomes were analyzed, including infection, rejection, and patient death, with a median follow-up of 5.3 years. Associations between DC levels and outcomes were assessed using logistic regression analysis and Cox proportional hazards models. Results: An independent association of mDC levels with post-transplant cytomegalovirus infection (adjusted odds ratio 7.0, P = 0.01) and patient death (adjusted hazard ratio 13.0, P = 0.015) was found. No associations were demonstrated between levels of either DC subtype and bacterial infections or rejection. Conclusions: Pre-transplant mDC deficiency is significantly associated with CMV infection and death after kidney transplantation.

Original languageEnglish (US)
Pages (from-to)618-625
Number of pages8
JournalTransplant Infectious Disease
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2012

Keywords

  • CMV infection
  • Dendritic cells
  • Immune monitoring
  • Mortality risk
  • Outcomes

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus infection and death after kidney transplantation'. Together they form a unique fingerprint.

  • Cite this

    Sun, Q., Hall, E. C., Huang, Y., Chen, P., Dibadj, K., Murawski, M., Shraybman, R., Van Kirk, K., Tang, V., Peng, R., Patton, P. R., Clare-Salzler, M. J., Kaplan, B., Segev, D. L., & Womer, K. L. (2012). Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus infection and death after kidney transplantation. Transplant Infectious Disease, 14(6), 618-625. https://doi.org/10.1111/j.1399-3062.2012.00750.x