Pre-transplant AT1R antibodies correlate with early allograft rejection

Alison J. Gareau, Chris Wiebe, Denise Pochinco, Ian W. Gibson, Julie Ho, David N. Rush, Peter W. Nickerson

Research output: Contribution to journalArticlepeer-review

Abstract

Studies investigating the potential pathogenic effects of non-HLA antibodies (Ab) have identified Ab against the angiotensin II type 1 receptor (AT1R-Ab) as a risk factor for rejection and kidney graft loss. This study sought to validate the risk of AT1R-Ab for acute rejection and to explore the role of other non-HLA Abs in this capacity. Pre- and post-transplant sera from a cohort of 101 patients (n = 453 samples total) were tested for AT1R-Ab and other non-HLA Ab using a commercially available ELISA kit and the Luminex platform, respectively. Patients positive for pre-transplant AT1R-Ab were more likely to develop de novo donor-specific Ab (dnDSA) compared to patients that were negative for AT1R-Ab (28% vs 10%, p = 0.027). Pre-transplant positivity for AT1R-Ab was associated with TCMR in the first year post-transplant (p = 0.034), but did not predict graft loss independent of dnDSA (p = 0.063). AT1R-Ab positivity was significantly associated with positivity for Ab against the endothelin A type 1 receptor (ETAR-Ab) inclusive of all study time points (p = 0.0021). Given the high prevalence of AT1R-Ab pre-transplant (20%) and its association with dnDSA and early TCMR, a prospective study to determine if more intense immunosuppression and/or AT1R blockade has an impact on outcomes in these patients is warranted.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalTransplant Immunology
Volume46
DOIs
StatePublished - Feb 2018
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation

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