Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis

Sabrina Paganoni, Theodore Hyman, Amy Shui, Peggy Allred, Matthew Harms, Jingxia Liu, Nicholas J Maragakis, David Schoenfeld, Hong Yu, Nazem Atassi, Merit Cudkowicz, Timothy M. Miller

Research output: Contribution to journalArticle

Abstract

Introduction: The aim of this study was to determine whether a history of pre-morbid type 2 diabetes mellitus (DM2) is a prognostic factor in amyotrophic lateral sclerosis (ALS). Methods: The relationship between DM2 and survival was analyzed in a study population consisting of 1,322 participants from 6 clinical trials. Results: Survival did not differ by diabetes status (log-rank test, P=0.98), but did differ by body mass index (BMI) (log-rank test, P=0.008). In multivariate analysis, there was no significant association between diabetes and survival (P=0.18), but the risk of reaching a survival endpoint decreased by 4% for each unit increase in baseline BMI (HR 0.96, 95% CI 0.94-0.99, P=0.001). DM2 was less prevalent among ALS clinical trial participants than predicted. Conclusions: A history of pre-morbid DM2 is not an independent prognostic factor in ALS clinical trial databases. The low DM2 prevalence rate should be examined in a large, prospective study to determine whether DM2 affects ALS risk.

Original languageEnglish (US)
Pages (from-to)339-343
Number of pages5
JournalMuscle and Nerve
Volume52
Issue number3
DOIs
StatePublished - Sep 1 2015

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Amyotrophic Lateral Sclerosis
Type 2 Diabetes Mellitus
Clinical Trials
Body Mass Index
Multivariate Analysis
Databases
Prospective Studies
Population

Keywords

  • ALS
  • BMI
  • Diabetes
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

Paganoni, S., Hyman, T., Shui, A., Allred, P., Harms, M., Liu, J., ... Miller, T. M. (2015). Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis. Muscle and Nerve, 52(3), 339-343. https://doi.org/10.1002/mus.24688

Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis. / Paganoni, Sabrina; Hyman, Theodore; Shui, Amy; Allred, Peggy; Harms, Matthew; Liu, Jingxia; Maragakis, Nicholas J; Schoenfeld, David; Yu, Hong; Atassi, Nazem; Cudkowicz, Merit; Miller, Timothy M.

In: Muscle and Nerve, Vol. 52, No. 3, 01.09.2015, p. 339-343.

Research output: Contribution to journalArticle

Paganoni, S, Hyman, T, Shui, A, Allred, P, Harms, M, Liu, J, Maragakis, NJ, Schoenfeld, D, Yu, H, Atassi, N, Cudkowicz, M & Miller, TM 2015, 'Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis', Muscle and Nerve, vol. 52, no. 3, pp. 339-343. https://doi.org/10.1002/mus.24688
Paganoni, Sabrina ; Hyman, Theodore ; Shui, Amy ; Allred, Peggy ; Harms, Matthew ; Liu, Jingxia ; Maragakis, Nicholas J ; Schoenfeld, David ; Yu, Hong ; Atassi, Nazem ; Cudkowicz, Merit ; Miller, Timothy M. / Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis. In: Muscle and Nerve. 2015 ; Vol. 52, No. 3. pp. 339-343.
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