Pre-morbid asociality in neuroleptic-resistant and neuroleptic-responsive schizophrenia

R. L. Findling, K. Jayathilake, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to evaluate whether childhood and adolescent premorbid asociality differed in neuroleptic-responsive and neuroleptic-resistant schizophrenia. Premorbid asociality was assessed with the Pre-morbid Asociality Adjustment Scale in 411 patients meeting DSM-III-R criteria for chronic schizophrenia or schizoaffective disorder categorized as being either neuroleptic-responsive or neuroleptic-resistant. Patterns of childhood and adolescent asociality were found to be different in neuroleptic-resistant and neuroleptic-responsive patients. Pre-morbid asociality during the pre-adult years was not consistently worse in patients with poor response to neuroleptic treatment. Greater impairment in late adolescent psychosexual functioning was predictive of poor outcome with regard to neuroleptic treatment.

Original languageEnglish (US)
Pages (from-to)1033-1041
Number of pages9
JournalPsychological medicine
Issue number5
StatePublished - Sep 1996

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


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