Abstract
Background: Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is becoming increasingly adopted for HIV prevention. Tenofovir can cause proximal tubular damage and chronic kidney disease in HIV-infected persons, but little is known regarding its nephrotoxic potential among HIV-uninfected persons. In this study, we evaluated the effects of PrEP on urine levels of the following: a1-microglobulin (a1m), a marker of impaired tubular reabsorption; albuminuria, a measure of glomerular injury; and total proteinuria. Setting: The Iniciativa Profilaxis Pre-Exposicion (iPrEx) study randomized HIV-seronegative men and transgender women who have sex with men to oral TDF/FTC or placebo. The iPrEx open-label extension (iPrEx-OLE) study enrolled former PrEP trial participants to receive open-label TDF/FTC. Methods: A cross-sectional analysis compared urine biomarker levels by study arm in iPrEx (N = 100 treatment arm, N = 100 placebo arm). Then, urine biomarker levels were compared before and after PrEP initiation in 109 participants of iPrEx-OLE. Results: In iPrEx, there were no significant differences in urine a1m, albuminuria, or proteinuria by treatment arm. In iPrEx-OLE, after 24 weeks on PrEP, urine a1m and proteinuria increased by 21% [95% confidence interval (CI): 10 to 33] and 18% (95% CI: 8 to 28), respectively. The prevalence of detectable a1m increased from 44% to 65% (P < 0.001) and estimated glomerular filtration rate declined by 4 mL/min/1.73 m2 (P < 0.001). There was no significant change in albuminuria (6%; 95% CI: -7% to 20%). Conclusion: PrEP with TDF/FTC was associated with a statistically significant rise in urine a1m and proteinuria after 6 months, suggesting that PrEP may result in subclinical tubule dysfunction.
Original language | English (US) |
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Pages (from-to) | 169-174 |
Number of pages | 6 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 78 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 2018 |
Externally published | Yes |
Keywords
- Alpha-1 microglobulin
- HIV prevention
- Kidney injury
- Nephrotoxicity
- Pre-exposure prophylaxis (PrEP)
- Tubular dysfunction
- Urine biomarkers
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)