Pre-erythrocytic malaria vaccines: identifying the targets.

Patrick E. Duffy, Tejram Sahu, Adovi Akue, Neta Milman, Charles Anderson

Research output: Contribution to journalReview article

Abstract

Pre-erythrocytic malaria vaccines target Plasmodium during its sporozoite and liver stages, and can prevent progression to blood-stage disease, which causes a million deaths each year. Whole organism sporozoite vaccines induce sterile immunity in animals and humans and guide subunit vaccine development. A recombinant protein-in-adjuvant pre-erythrocytic vaccine called RTS,S reduces clinical malaria without preventing infection in field studies and additional antigens may be required to achieve sterile immunity. Although few vaccine antigens have progressed to human testing, new insights into parasite biology, expression profiles and immunobiology have offered new targets for intervention. Future advances require human trials of additional antigens, as well as platforms to induce the durable antibody and cellular responses including CD8(+) T cells that contribute to sterile protection.

Original languageEnglish (US)
Pages (from-to)1261-1280
Number of pages20
JournalExpert review of vaccines
Volume11
Issue number10
DOIs
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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