Effective pre-clinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review we seek to outline the challenges at hand for effective pre-clinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated pre-clinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research. Specifically, we examine additional hardware that has been used to adapt clinical MRgFUS equipment to better position, constrain, and image pre-clinical subjects, as well as software solutions that have been used to extend the potential and capabilities of clinical devices.
|Original language||English (US)|
|Journal||IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control|
|State||Published - 2016|
ASJC Scopus subject areas
- Acoustics and Ultrasonics
- Electrical and Electronic Engineering