Pre-Clinical MRI-Guided Focused Ultrasound: A Review of Systems and Current Practices

Nicholas Ellens, Ari Partanen

Research output: Contribution to journalReview articlepeer-review


Effective pre-clinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review we seek to outline the challenges at hand for effective pre-clinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated pre-clinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research. Specifically, we examine additional hardware that has been used to adapt clinical MRgFUS equipment to better position, constrain, and image pre-clinical subjects, as well as software solutions that have been used to extend the potential and capabilities of clinical devices.

Original languageEnglish (US)
Article number7565574
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number99
StatePublished - 2016

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

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