Pre-clinical models of neurodevelopmental disorders: Focus on the cerebellum

Alexey Shevelkin, Chinezimuzo Ihenatu, Mikhail Pletnikov

Research output: Contribution to journalArticle

Abstract

Recent studies have advanced our understanding of the role of the cerebellum in non-motor behaviors. Abnormalities in the cerebellar structure have been demonstrated to produce changes in emotional, cognitive, and social behaviors resembling clinical manifestations observed in patients with autism spectrum disorders (ASD) and schizophrenia. Several animal models have been used to evaluate the effects of relevant environmental and genetic risk factors on the cerebellum development and function. However, very few models of ASD and schizophrenia selectively target the cerebellum and/or specific cell types within this structure. In this review, we critically evaluate the strength and weaknesses of these models. We will propose that the future progress in this field will require time- and cell type-specific manipulations of disease-relevant genes, not only selectively in the cerebellum, but also in frontal brain areas connected with the cerebellum. Such information can advance our knowledge of the cerebellar contribution to non-motor behaviors in mental health and disease.

Original languageEnglish (US)
Pages (from-to)177-194
Number of pages18
JournalReviews in the Neurosciences
Volume25
Issue number2
DOIs
StatePublished - 2014

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Cerebellum
Schizophrenia
Social Behavior
Mental Health
Animal Models
Neurodevelopmental Disorders
Brain
Genes
Autism Spectrum Disorder

Keywords

  • Animal model
  • Autism
  • Cerebellum
  • Purkinje cells
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pre-clinical models of neurodevelopmental disorders : Focus on the cerebellum. / Shevelkin, Alexey; Ihenatu, Chinezimuzo; Pletnikov, Mikhail.

In: Reviews in the Neurosciences, Vol. 25, No. 2, 2014, p. 177-194.

Research output: Contribution to journalArticle

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