Purpose: Pelvic fracture fixation is a challenging procedure that commonly relies on 2D fluoroscopic guidance to place guidewires within complex bone corridors. Prior work reported on a video-on-drill navigation system for guidewire insertion as a potential solution. Here, we assess performance across a range of hardware components to help guide the design of future system prototypes with respect to clinical requirements. Methods: The video-on-drill system uses a camera rigidly mounted on the drill and multimodality fiducial markers (optical and radio-opaque) to provide real-time trajectory visualization. This work reports on the selection of a new camera+lens configuration. Configurations were assessed across two cameras (referred to as the ArduCam and ELP) and five lens options (A45-A90). Clinical requirements were specified by an orthopaedic-surgeon in terms of the nominal drill operating distance (o •) and operating area (o ). Performance was evaluated in terms of the accuracy of fiducial marker pose estimation (δo •), and the field of view (FOV). Results: At matched FOV, the accuracy for the ELP camera was significantly better (p < 0.01) with median δo • of 1.26 mm (1.1 mm IQR) compared to the ArduCam [median δo • of 1.85 mm (2.0 mm IQR)]. The accuracy of the A45 and A55 lens was found to be suitable (δo • < 2 mm) while providing sufficient FOV at nominal drill operating conditions. Conclusion: With respect to application requirements, the camera+lens combination (ELP+Ardu55) was identified to provide the best performance, serving as an important precursor to future design iterations of the video-on-drill system.